Literature DB >> 22261119

Are Mycobacterium avium subsp. paratuberculosis and Epstein-Barr virus triggers of multiple sclerosis in Sardinia?

Davide Cossu1, Speranza Masala, Eleonora Cocco, Daniela Paccagnini, Jessica Frau, Maria Giovanna Marrosu, Leonardo A Sechi.   

Abstract

Sardinia acts as an ideal setting for multiple sclerosis (MS) studies because its prevalence of MS is one of the highest worldwide. Several pathogens have been investigated amongst 119 Sardinian MS patients and 117 healthy controls to determine whether they might have a role in triggering MS in genetically predisposed individuals. Mycobacterium avium subsp. paratuberculosis (MAP) and Epstein Barr virus DNA were detected in 27.5% and 17.3%, respectively, of the MS patients. Moreover an extremely high humoral immune response against MAP recombinant protein MAP FprB (homologous to human myelin P0) was observed, whereas no significant results were found against Mycobacterium tuberculosis FprA and Helicobacter pylori HP986 protein.

Entities:  

Mesh：

Substances：

Year:  2012        PMID： 22261119     DOI： 10.1177/1352458511433430

Source DB:  PubMed          Journal:  Mult Scler        ISSN： 1352-4585            Impact factor:   6.312


  11 in total

1.  Systematic and meta-analysis of Mycobacterium avium subsp. paratuberculosis related type 1 and type 2 diabetes mellitus.

Authors:  Temitope C Ekundayo; Ayodeji O Falade; Bright E Igere; Chidozie D Iwu; Mary A Adewoyin; Tosin A Olasehinde; Oluwatosin A Ijabadeniyi
Journal:  Sci Rep       Date:  2022-03-17       Impact factor: 4.379

Review 2.  The zoonotic potential of Mycobacterium avium ssp. paratuberculosis: a systematic review and meta-analyses of the evidence.

Authors:  L A Waddell; A Rajić; K D C Stärk; S A McEWEN
Journal:  Epidemiol Infect       Date:  2015-05-20       Impact factor: 4.434

Review 3.  Mycobacterium avium ss. paratuberculosis Zoonosis - The Hundred Year War - Beyond Crohn's Disease.

Authors:  Leonardo A Sechi; Coad Thomas Dow
Journal:  Front Immunol       Date:  2015-03-04       Impact factor: 7.561

4.  Relationship between Helicobacter pylori infection and multiple sclerosis.

Authors:  Emmanuel Gavalas; Jannis Kountouras; Marina Boziki; Christos Zavos; Stergios A Polyzos; Efthymia Vlachaki; Ioannis Venizelos; Dimitrios Tsiptsios; Georgia Deretzi
Journal:  Ann Gastroenterol       Date:  2015 Jul-Sep

5.  Humoral response against host-mimetic homologous epitopes of Mycobacterium avium subsp. paratuberculosis in Japanese multiple sclerosis patients.

Authors:  Davide Cossu; Kazumasa Yokoyama; Leonardo Antonio Sechi; Shigeru Otsubo; Yuji Tomizawa; Eiichi Momotani; Nobutaka Hattori
Journal:  Sci Rep       Date:  2016-06-30       Impact factor: 4.379

6.  Altered humoral immunity to mycobacterial antigens in Japanese patients affected by inflammatory demyelinating diseases of the central nervous system.

Authors:  Davide Cossu; Kazumasa Yokoyama; Yuji Tomizawa; Eiichi Momotani; Nobutaka Hattori
Journal:  Sci Rep       Date:  2017-06-09       Impact factor: 4.379

7.  Interaction between HLA-DRB1-DQB1 haplotypes in Sardinian multiple sclerosis population.

Authors:  Eleonora Cocco; Raffaele Murru; Gianna Costa; Amit Kumar; Enrico Pieroni; Cristina Melis; Luigi Barberini; Claudia Sardu; Lorena Lorefice; Giuseppe Fenu; Jessica Frau; Giancarlo Coghe; Nicola Carboni; Maria Giovanna Marrosu
Journal:  PLoS One       Date:  2013-04-08       Impact factor: 3.240

8.  Mycobacterium avium subsp. paratuberculosis in an Italian cohort of type 1 diabetes pediatric patients.

Authors:  Maria Luisa Manca Bitti; Speranza Masala; Francesca Capasso; Novella Rapini; Simona Piccinini; Federica Angelini; Andrea Pierantozzi; Roberta Lidano; Silvia Pietrosanti; Daniela Paccagnini; Leonardo A Sechi
Journal:  Clin Dev Immunol       Date:  2012-07-11

9.  Recognition of zinc transporter 8 and MAP3865c homologous epitopes by Hashimoto's thyroiditis subjects from Sardinia: a common target with type 1 diabetes?

Authors:  Speranza Masala; Davide Cossu; Mario Palermo; Leonardo Antonio Sechi
Journal:  PLoS One       Date:  2014-05-15       Impact factor: 3.240

10.  Epstein Barr Virus and Mycobacterium avium subsp. paratuberculosis peptides are recognized in sera and cerebrospinal fluid of MS patients.

Authors:  Giuseppe Mameli; Eleonora Cocco; Jessica Frau; Maria Giovanna Marrosu; Leonardo Antonio Sechi
Journal:  Sci Rep       Date:  2016-03-09       Impact factor: 4.379
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.