Literature DB >> 22260700

ERK5 and its role in tumour development.

Pamela A Lochhead1, Rebecca Gilley, Simon J Cook.   

Abstract

The MEK5 [MAPK (mitogen-activated protein kinase)/ERK (extracellular-signal-regulated kinase) kinase 5]/ERK5 pathway is the least well studied MAPK signalling module. It has been proposed to play a role in the pathology of cancer. In the present paper, we review the role of the MEK5/ERK5 pathway using the 'hallmarks of cancer' as a framework and consider how this pathway is deregulated. As well as playing a key role in endothelial cell survival and tubular morphogenesis during tumour neovascularization, ERK5 is also emerging as a regulator of tumour cell invasion and migration. Several oncogenes can stimulate ERK5 activity, and protein levels are increased by a novel amplification at chromosome locus 17p11 and by down-regulation of the microRNAs miR-143 and miR-145. Together, these finding underscore the case for further investigation into understanding the role of ERK5 in cancer.

Entities:  

Mesh：

Substances：

Year:  2012        PMID： 22260700     DOI： 10.1042/BST20110663

Source DB:  PubMed          Journal:  Biochem Soc Trans        ISSN： 0300-5127            Impact factor:   5.407


  34 in total

1.  Can tumor cells proliferate without ERK5?

Authors:  Emanuele Giurisato; Cathy Tournier
Journal:  Cell Cycle       Date:  2016       Impact factor: 4.534

2.  Cell-specific translational profiling in acute kidney injury.

Authors:  Jing Liu; A Michaela Krautzberger; Shannan H Sui; Oliver M Hofmann; Ying Chen; Manfred Baetscher; Ivica Grgic; Sanjeev Kumar; Benjamin D Humphreys; Benjamin Humphreys; Winston A Hide; Andrew P McMahon
Journal:  J Clin Invest       Date:  2014-02-24       Impact factor: 14.808

3.  Abituzumab Targeting of αV-Class Integrins Inhibits Prostate Cancer Progression.

Authors:  Yuan Jiang; Jinlu Dai; Zhi Yao; Greg Shelley; Evan T Keller
Journal:  Mol Cancer Res       Date:  2017-03-17       Impact factor: 5.852

4.  ERK5 kinase activity is dispensable for cellular immune response and proliferation.

Authors:  Emme C K Lin; Christopher M Amantea; Tyzoon K Nomanbhoy; Helge Weissig; Junichi Ishiyama; Yi Hu; Shyama Sidique; Bei Li; John W Kozarich; Jonathan S Rosenblum
Journal:  Proc Natl Acad Sci U S A       Date:  2016-09-27       Impact factor: 11.205

Review 5.  Mechanisms of adaptation of the hepatic vasculature to the deteriorating conditions of blood circulation in liver cirrhosis.

Authors:  Dmitry Victorovich Garbuzenko; Nikolay Olegovich Arefyev; Dmitry Vladimirovich Belov
Journal:  World J Hepatol       Date:  2016-06-08

6.  TRAF1 Is Critical for DMBA/Solar UVR-Induced Skin Carcinogenesis.

Authors:  Hiroyuki Yamamoto; Joohyun Ryu; Eli Min; Naomi Oi; Ruihua Bai; Tatyana A Zykova; Dong Hoon Yu; Kenji Moriyama; Ann M Bode; Zigang Dong
Journal:  J Invest Dermatol       Date:  2017-01-25       Impact factor: 8.551

Review 7.  Growth factor transduction pathways: paradigm of anti-neoplastic targeted therapy.

Authors:  Francesca Carlomagno; Mario Chiariello
Journal:  J Mol Med (Berl)       Date:  2014-06-08       Impact factor: 4.599

8.  Functions of microRNA-143 in the apoptosis, invasion and migration of nasopharyngeal carcinoma.

Authors:  Jin-Hui Chen; Rui Yang; Wei Zhang; Yong-Ping Wang
Journal:  Exp Ther Med       Date:  2016-10-27       Impact factor: 2.447

9.  Shear Stress Induces Change in Extracellular Signal-Regulated Kinase 5 Levels with Sustained Activation under Disturbed and Continuous Laminar Flow.

Authors:  S Y Shalaby; G Chitragari; B J Sumpio; B E Sumpio
Journal:  Int J Angiol       Date:  2017-02-25

10.  miR-143 is associated with proliferation and apoptosis involving ERK5 in HeLa cells.

Authors:  Fang Zheng; Jiahe Zhang; Siyu Luo; Jing Yi; Ping Wang; Quanqing Zheng; Yurong Wen
Journal:  Oncol Lett       Date:  2016-08-16       Impact factor: 2.967
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.