Literature DB >> 22260665

Role of Epac in brain and heart.

Anne-Coline Laurent1, Magali Breckler, Magali Berthouze, Frank Lezoualc'h.   

Abstract

Epacs (exchange proteins directly activated by cAMP) are guanine-nucleotide-exchange factors for the Ras-like small GTPases Rap1 and Rap2. Epacs were discovered in 1998 as new sensors for the second messenger cAMP acting in parallel to PKA (protein kinase A). As cAMP regulates many important physiological functions in brain and heart, the existence of Epacs raises many questions regarding their role in these tissues. The present review focuses on the biological roles and signalling pathways of Epacs in neurons and cardiac myocytes. We discuss the potential involvement of Epacs in the manifestation of cardiac and central diseases such as cardiac hypertrophy and memory disorders.

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Year:  2012        PMID： 22260665     DOI： 10.1042/BST20110642

Source DB:  PubMed          Journal:  Biochem Soc Trans        ISSN： 0300-5127            Impact factor:   5.407


  16 in total

Review 1.  PDE4 as a target for cognition enhancement.

Authors:  Wito Richter; Frank S Menniti; Han-Ting Zhang; Marco Conti
Journal:  Expert Opin Ther Targets       Date:  2013-07-25       Impact factor: 6.902

2.  Deficiency of the purine metabolic gene HPRT dysregulates microRNA-17 family cluster and guanine-based cellular functions: a role for EPAC in Lesch-Nyhan syndrome.

Authors:  Ghiabe-Henri Guibinga; Fiona Murray; Nikki Barron; William Pandori; Gorjan Hrustanovic
Journal:  Hum Mol Genet       Date:  2013-06-25       Impact factor: 6.150

3.  Melatonin attenuates scopolamine-induced memory/synaptic disorder by rescuing EPACs/miR-124/Egr1 pathway.

Authors:  Xiong Wang; Zhi-Hao Wang; Yuan-Yuan Wu; Hui Tang; Lu Tan; Xiang Wang; Xin-Ya Gao; Yan-Si Xiong; Dan Liu; Jian-Zhi Wang; Ling-Qiang Zhu
Journal:  Mol Neurobiol       Date:  2012-10-07       Impact factor: 5.590

4.  Rap1b in smooth muscle and endothelium is required for maintenance of vascular tone and normal blood pressure.

Authors:  Sribalaji Lakshmikanthan; Bartosz J Zieba; Zhi-Dong Ge; Ko Momotani; Xiaodong Zheng; Hayley Lund; Mykhaylo V Artamonov; Jason E Maas; Aniko Szabo; David X Zhang; John A Auchampach; David L Mattson; Avril V Somlyo; Magdalena Chrzanowska-Wodnicka
Journal:  Arterioscler Thromb Vasc Biol       Date:  2014-05-01       Impact factor: 8.311

5.  UCR1C is a novel activator of phosphodiesterase 4 (PDE4) long isoforms and attenuates cardiomyocyte hypertrophy.

Authors:  Li Wang; Brian T Burmeister; Keven R Johnson; George S Baillie; Andrei V Karginov; Randal A Skidgel; John P O'Bryan; Graeme K Carnegie
Journal:  Cell Signal       Date:  2015-02-12       Impact factor: 4.315

6.  Allosteric inhibition of Epac: computational modeling and experimental validation to identify allosteric sites and inhibitors.

Authors:  Loren M Brown; Kathleen E Rogers; Nakon Aroonsakool; J Andrew McCammon; Paul A Insel
Journal:  J Biol Chem       Date:  2014-09-02       Impact factor: 5.157

Review 7.  Recent advances in the discovery of small molecules targeting exchange proteins directly activated by cAMP (EPAC).

Authors:  Haijun Chen; Christopher Wild; Xiaobin Zhou; Na Ye; Xiaodong Cheng; Jia Zhou
Journal:  J Med Chem       Date:  2013-11-27       Impact factor: 7.446

Review 8.  Distinct functions for Rap1 signaling in vascular morphogenesis and dysfunction.

Authors:  Magdalena Chrzanowska-Wodnicka
Journal:  Exp Cell Res       Date:  2013-08-02       Impact factor: 3.905

Review 9.  cAMP and mitochondria.

Authors:  Federica Valsecchi; Lavoisier S Ramos-Espiritu; Jochen Buck; Lonny R Levin; Giovanni Manfredi
Journal:  Physiology (Bethesda)       Date:  2013-05

10.  Structure-activity relationships of 2-substituted phenyl-N-phenyl-2-oxoacetohydrazonoyl cyanides as novel antagonists of exchange proteins directly activated by cAMP (EPACs).

Authors:  Zhiqing Liu; Yingmin Zhu; Haiying Chen; Pingyuan Wang; Fang C Mei; Na Ye; Xiaodong Cheng; Jia Zhou
Journal:  Bioorg Med Chem Lett       Date:  2017-10-25       Impact factor: 2.823
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