Literature DB >> 22260257

Melodinines M-U, cytotoxic alkaloids from Melodinus suaveolens.

Ya-Ping Liu1, Yan Li, Xiang-Hai Cai, Xing-Yao Li, Ling-Mei Kong, Gui-Guang Cheng, Xiao-Dong Luo.   

Abstract

Nine new alkaloids, melodinines M-U (1-9), and 11 known alkaloids were isolated from Melodinus suaveolens. The new structures were elucidated by extensive NMR and mass spectroscopic analyses and comparison to known compounds. All compounds were evaluated for their cytotoxicity against five human cancer cell lines. Compounds 6, 11, and 16 showed significant cytotoxicity.

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Year:  2012        PMID： 22260257     DOI： 10.1021/np2009169

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  7 in total

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Authors:  Jinfeng Kang; Todd R Lewis; Alex Gardner; Rodrigo B Andrade; Rongsheng E Wang
Journal:  Org Biomol Chem       Date:  2022-05-18       Impact factor: 3.890

2.  Acetylcholinesterase immobilized capillary reactors coupled to protein coated magnetic beads: a new tool for plant extract ligand screening.

Authors:  Kenia Lourenço Vanzolini; Zhengjin Jiang; Xiaoqi Zhang; Lucas Campos Curcino Vieira; Arlene Gonçalvez Corrêa; Carmen Lucia Cardoso; Quezia Bezerra Cass; Ruin Moaddel
Journal:  Talanta       Date:  2013-07-31       Impact factor: 6.057

3.  Bisleuconothine A, a bisindole alkaloid, inhibits colorectal cancer cell in vitro and in vivo targeting Wnt signaling.

Authors:  Ling-Mei Kong; Tao Feng; Yuan-Yuan Wang; Xing-Yao Li; Zhen-Nan Ye; Tao An; Chen Qing; Xiao-Dong Luo; Yan Li
Journal:  Oncotarget       Date:  2016-03-01

4.  Indole Glycosides from Aqueous Fraction of Strychnos nitida.

Authors:  Bei Wang; Zhi Dai; Lu Liu; Xin Wei; Pei-Feng Zhu; Hao-Fei Yu; Ya-Ping Liu; Xiao-Dong Luo
Journal:  Nat Prod Bioprospect       Date:  2016-11-09

5.  Cytotoxic Indole Alkaloid 3α-Acetonyltabersonine Induces Glioblastoma Apoptosis via Inhibition of DNA Damage Repair.

Authors:  Yuan Li; Yunli Zhao; Xia Zhou; Wei Ni; Zhi Dai; Dong Yang; Junjun Hao; Lin Luo; Yaping Liu; Xiaodong Luo; Xudong Zhao
Journal:  Toxins (Basel)       Date:  2017-04-28       Impact factor: 4.546

6.  Sustainable Syntheses of (-)-Jerantinines A & E and Structural Characterisation of the Jerantinine-Tubulin Complex at the Colchicine Binding Site.

Authors:  Christopher J Smedley; Paul A Stanley; Mohannad E Qazzaz; Andrea E Prota; Natacha Olieric; Hilary Collins; Harry Eastman; Andrew S Barrow; Kuan-Hon Lim; Toh-Seok Kam; Brian J Smith; Hendrika M Duivenvoorden; Belinda S Parker; Tracey D Bradshaw; Michel O Steinmetz; John E Moses
Journal:  Sci Rep       Date:  2018-07-13       Impact factor: 4.379

7.  Bousmekines A-E, New Alkaloids from Two Bousigonia Species: B.angustifolia and B. mekongensis.

Authors:  Zong-Qing Huo; Qian Zhao; Wen-Tao Zhu; Xiao-Jiang Hao; Yu Zhang
Journal:  Nat Prod Bioprospect       Date:  2020-11-03
  7 in total

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