S Kocsi1, G Demeter, J Fogas, D Erces, J Kaszaki, Z Molnár. 1. Department of Anaesthesiology and Intensive Therapy, Faculty of Medicine, University of Szeged, Szeged, Hungary. kocsi.szilvia@gmail.com
Abstract
BACKGROUND: Red blood cell transfusion is done primarily as a means to improve oxygen delivery (DO₂). Current transfusion guidelines are based solely on hemoglobin levels, regardless of actual DO₂ need. As central venous oxygen saturation (ScvO₂) may reflect imbalances in DO₂ and consumption (VO₂) the aim of this study was to investigate the value of ScvO₂ as an indicator of oxygen balance in isovolemic anemia. METHODS: After splenectomy, anesthetized Vietnamese mini pigs (n = 13, weight range: 18-30 kg) underwent controlled bleeding in five stages (T₀-T₅). During each stage approximately 10% of the estimated starting total blood volume was removed and immediately replaced with an equal volume of colloid. Hemodynamic measurements and blood gas analysis were then performed. RESULTS: Each stage of bleeding resulted in a significant fall in hemoglobin, T₀ : 125 (113-134) to T(5) : 49 (43-55) g/l [T₀ : 7.7 (6.9-8.2) to T₅ : 3.0 (2.6-3.4) mmol/l]. The O₂-extraction (VO₂/DO₂) increased significantly only from T₃ : 35 (21-40) %, P < 0.05. The change of ScvO₂ showed a similar pattern and dropped below the physiological threshold of 70% at T₄ : 68 (61-76) %. At this point, hemoglobin was below the recommended transfusion trigger value, 59 (53-67) g/l [3.6 (3.3-4.1) mmol/l]. There was a strong significant association between ScvO₂< 70%) and VO₂/DO₂ > 30%): r = -0.71, r² = 0.50, P < 0.001. CONCLUSION: The results of this study show that ScvO₂ reflects changes of VO₂/DO₂ in isovolemic anemia better than Hb alone, therefore it may be used as an additional indicator of blood transfusion in clinical practice.
BACKGROUND: Red blood cell transfusion is done primarily as a means to improve oxygen delivery (DO₂). Current transfusion guidelines are based solely on hemoglobin levels, regardless of actual DO₂ need. As central venous oxygen saturation (ScvO₂) may reflect imbalances in DO₂ and consumption (VO₂) the aim of this study was to investigate the value of ScvO₂ as an indicator of oxygen balance in isovolemic anemia. METHODS: After splenectomy, anesthetized Vietnamese mini pigs (n = 13, weight range: 18-30 kg) underwent controlled bleeding in five stages (T₀-T₅). During each stage approximately 10% of the estimated starting total blood volume was removed and immediately replaced with an equal volume of colloid. Hemodynamic measurements and blood gas analysis were then performed. RESULTS: Each stage of bleeding resulted in a significant fall in hemoglobin, T₀ : 125 (113-134) to T(5) : 49 (43-55) g/l [T₀ : 7.7 (6.9-8.2) to T₅ : 3.0 (2.6-3.4) mmol/l]. The O₂-extraction (VO₂/DO₂) increased significantly only from T₃ : 35 (21-40) %, P < 0.05. The change of ScvO₂ showed a similar pattern and dropped below the physiological threshold of 70% at T₄ : 68 (61-76) %. At this point, hemoglobin was below the recommended transfusion trigger value, 59 (53-67) g/l [3.6 (3.3-4.1) mmol/l]. There was a strong significant association between ScvO₂< 70%) and VO₂/DO₂ > 30%): r = -0.71, r² = 0.50, P < 0.001. CONCLUSION: The results of this study show that ScvO₂ reflects changes of VO₂/DO₂ in isovolemic anemia better than Hb alone, therefore it may be used as an additional indicator of blood transfusion in clinical practice.
Authors: Péter Palágyi; József Kaszaki; Andrea Rostás; Dániel Érces; Márton Németh; Mihály Boros; Zsolt Molnár Journal: Biomed Res Int Date: 2015-10-04 Impact factor: 3.411