Literature DB >> 22259649

Improvement of venous leg ulcers with androgen replacement therapy in a patient with undiagnosed klinefelter syndrome.

Shwetha Thukuntla1, Pratima Kumar.   

Abstract

Klinefelter syndrome (KS) is the most common genetic form of male hypogonadism. The majority (80-90%) of patients have 47, XXY karyotype while mosaicism is seen in only 10-20% of patients. Leg ulcers may be a presenting symptom of KS with a prevalence of 6-13%. Treatment with testosterone has been reported to improve the ulcers.

Entities:  

Keywords:  androgen therapy; klinefelter syndrome; leg ulcers; mosaicism; plasminogen activator inhibitor

Year:  2011        PMID： 22259649      PMCID： PMC3256338          DOI： 10.4161/derm.3.4.15333

Source DB:  PubMed          Journal:  Dermatoendocrinol        ISSN： 1938-1972


  8 in total

1.  Association between venous leg ulcers and sex chromosome anomalies in men.

Authors:  Cornelia Gattringer; Christine Scheurecker; Reinhard Höpfl; Hansgeorg Müller
Journal:  Acta Derm Venereol       Date:  2010-11       Impact factor: 4.437

Review 2.  Klinefelter's syndrome as a model for skin changes in venous insufficiency.

Authors:  J C Veraart; K Hamulyak; H A Neumann
Journal:  Wien Med Wochenschr       Date:  1994

3.  Leg ulcer in Klinefelter's syndrome.

Authors:  K Igawa; K Nishioka
Journal:  J Eur Acad Dermatol Venereol       Date:  2003-01       Impact factor: 6.166

Review 4.  Leg ulcers in Klinefelter's syndrome--further evidence for an involvement of plasminogen activator inhibitor-1.

Authors:  T M Zollner; J C Veraart; M Wolter; S Hesse; B Villemur; A Wenke; R J Werner; W H Boehncke; S S Jost; I Scharrer; R Kaufmann
Journal:  Br J Dermatol       Date:  1997-03       Impact factor: 9.302

5.  Increased plasma activity of plasminogen activator inhibitor 1 (PAI-1) in two patients with Klinefelter's syndrome complicated by leg ulcers.

Authors:  J C Veraart; K Hamulyak; H A Neumann; J Engelen
Journal:  Br J Dermatol       Date:  1994-05       Impact factor: 9.302

6.  Plasminogen activator inhibitor 1 (PAI-1) levels in patients with chronic venous leg ulceration.

Authors:  S H Ibbotson; A M Layton; J A Davies; M J Goodfield
Journal:  Br J Dermatol       Date:  1994-11       Impact factor: 9.302

7.  [Leg ulcer and Klinefelter syndrome].

Authors:  B Villemur; H Truche; G Pernod; M P De Angelis; J C Beani; S Halimi; M Collomb; A Franco; H Guidicelli
Journal:  J Mal Vasc       Date:  1995

Review 8.  Klinefelter's syndrome presenting with leg ulcers.

Authors:  Helena Martinez De Morentin; Roni P Dodiuk-Gad; Sarah Brenner
Journal:  Skinmed       Date:  2004 Sep-Oct
  8 in total
  1 in total

1.  Hormones and skin: A never ending love story!

Authors:  Jörg Reichrath
Journal:  Dermatoendocrinol       Date:  2011-10-01
  1 in total

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