Literature DB >> 22257852

Signaling: An oxysterol ligand for Smoothened.

Hayley J Sharpe, Frederic J de Sauvage.   

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Year:  2012        PMID： 22257852     DOI： 10.1038/nchembio.774

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


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  9 in total

1.  Small molecule antagonists in distinct binding modes inhibit drug-resistant mutant of smoothened.

Authors:  Haiyan Tao; Qihui Jin; Dong-In Koo; Xuebin Liao; Nathan P Englund; Yan Wang; Arun Ramamurthy; Peter G Schultz; Marion Dorsch; Joseph Kelleher; Xu Wu
Journal:  Chem Biol       Date:  2011-04-22

2.  Structural ties between cholesterol transport and morphogen signaling.

Authors:  J Fernando Bazan; Frederic J de Sauvage
Journal:  Cell       Date:  2009-09-18       Impact factor: 41.582

3.  Mutations in the sterol-sensing domain of Patched suggest a role for vesicular trafficking in Smoothened regulation.

Authors:  H Strutt; C Thomas; Y Nakano; D Stark; B Neave; A M Taylor; P W Ingham
Journal:  Curr Biol       Date:  2001-04-17       Impact factor: 10.834

4.  Oxysterols direct B-cell migration through EBI2.

Authors:  Changlu Liu; Xia V Yang; Jiejun Wu; Chester Kuei; Neelakandha S Mani; Li Zhang; Jingxue Yu; Steven W Sutton; Ning Qin; Homayon Banie; Lars Karlsson; Siquan Sun; Timothy W Lovenberg
Journal:  Nature       Date:  2011-07-27       Impact factor: 49.962

5.  Small molecule modulation of Smoothened activity.

Authors:  James K Chen; Jussi Taipale; Keith E Young; Tapan Maiti; Philip A Beachy
Journal:  Proc Natl Acad Sci U S A       Date:  2002-10-21       Impact factor: 11.205

6.  Evidence for allosteric interactions of antagonist binding to the smoothened receptor.

Authors:  Cynthia M Rominger; Wei-Lin Tiger Bee; Robert A Copeland; Elizabeth A Davenport; Aidan Gilmartin; Richard Gontarek; Keith R Hornberger; Lorena A Kallal; Zhihong Lai; Kenneth Lawrie; Quinn Lu; Lynette McMillan; Maggie Truong; Peter J Tummino; Brandon Turunen; Matthew Will; William J Zuercher; David H Rominger
Journal:  J Pharmacol Exp Ther       Date:  2009-03-20       Impact factor: 4.030

7.  Oxysterols direct immune cell migration via EBI2.

Authors:  Sébastien Hannedouche; Juan Zhang; Tangsheng Yi; Weijun Shen; Deborah Nguyen; João P Pereira; Danilo Guerini; Birgit U Baumgarten; Silvio Roggo; Ben Wen; Richard Knochenmuss; Sophie Noël; Francois Gessier; Lisa M Kelly; Mirka Vanek; Stephane Laurent; Inga Preuss; Charlotte Miault; Isabelle Christen; Ratna Karuna; Wei Li; Dong-In Koo; Thomas Suply; Christian Schmedt; Eric C Peters; Rocco Falchetto; Andreas Katopodis; Carsten Spanka; Marie-Odile Roy; Michel Detheux; Yu Alice Chen; Peter G Schultz; Charles Y Cho; Klaus Seuwen; Jason G Cyster; Andreas W Sailer
Journal:  Nature       Date:  2011-07-27       Impact factor: 49.962

8.  Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells.

Authors:  Ryan B Corcoran; Matthew P Scott
Journal:  Proc Natl Acad Sci U S A       Date:  2006-05-17       Impact factor: 11.205

9.  Oxysterols are allosteric activators of the oncoprotein Smoothened.

Authors:  Sigrid Nachtergaele; Laurel K Mydock; Kathiresan Krishnan; Jayan Rammohan; Paul H Schlesinger; Douglas F Covey; Rajat Rohatgi
Journal:  Nat Chem Biol       Date:  2012-01-08       Impact factor: 15.040
  9 in total
  3 in total

1.  Highly automated nano-LC/MS-based approach for thousand cell-scale quantification of side chain-hydroxylated oxysterols.

Authors:  Hanne Roberg-Larsen; Kaja Lund; Tore Vehus; Nina Solberg; Caroline Vesterdal; Dorna Misaghian; Petter Angell Olsen; Stefan Krauss; Steven Ray Wilson; Elsa Lundanes
Journal:  J Lipid Res       Date:  2014-05-02       Impact factor: 5.922

2.  Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling.

Authors:  Sigrid Nachtergaele; Daniel M Whalen; Laurel K Mydock; Zhonghua Zhao; Tomas Malinauskas; Kathiresan Krishnan; Philip W Ingham; Douglas F Covey; Christian Siebold; Rajat Rohatgi
Journal:  Elife       Date:  2013-10-29       Impact factor: 8.140

Review 3.  Hedgehog signaling pathway and its targets for treatment in basal cell carcinoma.

Authors:  Danilo Cucchi; Maria Anna Occhione; Alberto Gulino; Enrico De Smaele
Journal:  J Exp Pharmacol       Date:  2012-12-14
  3 in total

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