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Literature DB >> 2225539

Methotrexate and trimethoprim-sulphamethoxazole--a potentially hazardous combination.

Abstract

A 74-year-old woman had been treated with methotrexate over 2 years for rheumatoid arthritis. She was admitted to the hospital because of non-healing leg ulcers. After being treated with trimethoprim-sulphamethoxazole for a urinary-tract infection, she developed severe pancytopenia, followed by pneumonia and septic shock. The patient died shortly after. Concomitant treatment with methotrexate and sulphonamides should be strongly discouraged.

Entities: Chemical Disease Species

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Year: 1990 PMID： 2225539 DOI： 10.1111/j.1365-2230.1990.tb02113.x

Source DB: PubMed Journal: Clin Exp Dermatol ISSN： 0307-6938 Impact factor: 3.470

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Cited

14 in total

1. Methotrexate-induced pancytopenia associated with co-prescription of penicillin and trimethoprim.

Authors: Navtej Sathi; Julie Dawson
Journal: Clin Rheumatol Date: 2006-08-29 Impact factor: 2.980

Review 2. Will pharmacogenetics allow better prediction of methotrexate toxicity and efficacy in patients with rheumatoid arthritis?

Authors: P Ranganathan; S Eisen; W M Yokoyama; H L McLeod
Journal: Ann Rheum Dis Date: 2003-01 Impact factor: 19.103

Methotrexate and trimethoprim-sulphamethoxazole--a potentially hazardous combination.

1. Methotrexate-induced pancytopenia associated with co-prescription of penicillin and trimethoprim.

Review 2. Will pharmacogenetics allow better prediction of methotrexate toxicity and efficacy in patients with rheumatoid arthritis?

3. Methotrexate and trimethoprim-sulfamethoxazole: toxicity from this combination continues to occur.

4. Thrombocytopenia in patients with rheumatoid arthritis on long-term treatment with low dose methotrexate.

Review 5. Pharmacological therapy for Wegener's granulomatosis.

Review 6. Pharmacokinetics and pharmacodynamics of methotrexate in non-neoplastic diseases.

Review 7. Methotrexate in juvenile rheumatoid arthritis. Do the benefits outweigh the risks?

8. Safety of the concomitant use of methotrexate and a prophylactic dose of trimethoprim-sulfamethoxazole.

Review 9. A risk-benefit assessment of slow-acting antirheumatic drugs in rheumatoid arthritis.

Review 10. Clinical pharmacology and modification of autoimmunity and inflammation in rheumatoid disease.