Literature DB >> 22255381

Stochastic simulation of cardiac ventricular myocyte calcium dynamics and waves.

Hoang-Trong Minh Tuan1, George S B Williams, Aristide C Chikando, Eric A Sobie, W Jonathan Lederer, M Saleet Jafri.   

Abstract

A three dimensional model of calcium dynamics in the rat ventricular myocyte was developed to study the mechanism of calcium homeostasis and pathological calcium dynamics during calcium overload. The model contains 20,000 calcium release units (CRUs) each containing 49 ryanodine receptors. The model simulates calcium sparks with a realistic spontaneous calcium spark rate. It suggests that in addition to the calcium spark-based leak, there is an invisible calcium leak caused by the stochastic opening of a small number of ryanodine receptors in each CRU without triggering a calcium spark. The model also explores the mechanism of calcium wave propagation between release sites under the conditions of calcium overload.

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Year:  2011        PMID： 22255381      PMCID： PMC3538105          DOI： 10.1109/IEMBS.2011.6091158

Source DB:  PubMed          Journal:  Conf Proc IEEE Eng Med Biol Soc        ISSN： 1557-170X


  14 in total

1.  Shape, size, and distribution of Ca(2+) release units and couplons in skeletal and cardiac muscles.

Authors:  C Franzini-Armstrong; F Protasi; V Ramesh
Journal:  Biophys J       Date:  1999-09       Impact factor: 4.033

2.  Ca sparks do not explain all ryanodine receptor-mediated SR Ca leak in mouse ventricular myocytes.

Authors:  Demetrio J Santiago; Jerald W Curran; Donald M Bers; W J Lederer; Michael D Stern; Eduardo Ríos; Thomas R Shannon
Journal:  Biophys J       Date:  2010-05-19       Impact factor: 4.033

3.  A stochastic automata network descriptor for Markov chain models of instantaneously coupled intracellular Ca2+ channels.

Authors:  Vien Nguyen; Roy Mathias; Gregory D Smith
Journal:  Bull Math Biol       Date:  2005-05       Impact factor: 1.758

4.  Three-dimensional distribution of ryanodine receptor clusters in cardiac myocytes.

Authors:  Ye Chen-Izu; Stacey L McCulle; Chris W Ward; Christian Soeller; Bryan M Allen; Cal Rabang; Mark B Cannell; C William Balke; Leighton T Izu
Journal:  Biophys J       Date:  2006-04-07       Impact factor: 4.033

Review 5.  The Ca 2+ leak paradox and rogue ryanodine receptors: SR Ca 2+ efflux theory and practice.

Authors:  Eric A Sobie; Silvia Guatimosim; Leticia Gómez-Viquez; Long-Sheng Song; Hali Hartmann; M Saleet Jafri; W J Lederer
Journal:  Prog Biophys Mol Biol       Date:  2005-07-18       Impact factor: 3.667

6.  Effects of rapid buffers on Ca2+ diffusion and Ca2+ oscillations.

Authors:  J Wagner; J Keizer
Journal:  Biophys J       Date:  1994-07       Impact factor: 4.033

7.  Cardiac Ca2+ dynamics: the roles of ryanodine receptor adaptation and sarcoplasmic reticulum load.

Authors:  M S Jafri; J J Rice; R L Winslow
Journal:  Biophys J       Date:  1998-03       Impact factor: 4.033

8.  Ca²+ spark-dependent and -independent sarcoplasmic reticulum Ca²+ leak in normal and failing rabbit ventricular myocytes.

Authors:  Aleksey V Zima; Elisa Bovo; Donald M Bers; Lothar A Blatter
Journal:  J Physiol       Date:  2010-10-20       Impact factor: 5.182

9.  On the roles of Ca2+ diffusion, Ca2+ buffers, and the endoplasmic reticulum in IP3-induced Ca2+ waves.

Authors:  M S Jafri; J Keizer
Journal:  Biophys J       Date:  1995-11       Impact factor: 4.033

10.  A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes.

Authors:  C H Luo; Y Rudy
Journal:  Circ Res       Date:  1994-06       Impact factor: 17.367
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  3 in total

1.  Calcium Sparks in the Heart: Dynamics and Regulation.

Authors:  Tuan M Hoang-Trong; Aman Ullah; M Saleet Jafri
Journal:  Res Rep Biol       Date:  2015-10-16

2.  Hierarchical clustering of ryanodine receptors enables emergence of a calcium clock in sinoatrial node cells.

Authors:  Michael D Stern; Larissa A Maltseva; Magdalena Juhaszova; Steven J Sollott; Edward G Lakatta; Victor A Maltsev
Journal:  J Gen Physiol       Date:  2014-05       Impact factor: 4.086

3.  Computational cardiology and risk stratification for sudden cardiac death: one of the grand challenges for cardiology in the 21st century.

Authors:  Adam P Hill; Matthew D Perry; Najah Abi-Gerges; Jean-Philippe Couderc; Bernard Fermini; Jules C Hancox; Bjorn C Knollmann; Gary R Mirams; Jon Skinner; Wojciech Zareba; Jamie I Vandenberg
Journal:  J Physiol       Date:  2016-06-09       Impact factor: 5.182
  3 in total

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