| Literature DB >> 22255377 |
Robert K Amanfu1, James B Muller, Jeffrey J Saucerman.
Abstract
Intracellular Ca(2+) dynamics act as a key link between the electrical and mechanical activity of the heart. Here we present a method for high-throughput measurement, automated cell segmentation and signal analysis of Ca(2+) transients in isolated adult ventricular myocytes. In addition to increasing experimental throughput ~10-fold compared to conventional approaches, this approach allows the study of individual cell-cell variability and relationships between Ca(2+) signaling and cell morphology.Entities:
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Year: 2011 PMID： 22255377 PMCID： PMC3261511 DOI： 10.1109/IEMBS.2011.6091154
Source DB: PubMed Journal: Conf Proc IEEE Eng Med Biol Soc ISSN： 1557-170X