Literature DB >> 22254412

GPGPU accelerated cardiac arrhythmia simulations.

Wei Wang1, H Howie Huang, Matthew Kay, John Cavazos.   

Abstract

Computational modeling of cardiac electrophysiology is a powerful tool for studying arrhythmia mechanisms. In particular, cardiac models are useful for gaining insights into experimental studies, and in the foreseeable future they will be used by clinicians to improve therapy for the patients suffering from complex arrhythmias. Such models are highly intricate, both in their geometric structure and in the equations that represent myocyte electrophysiology. For these models to be useful in a clinical setting, cost-effective solutions for solving the models in real time must be developed. In this work, we hypothesized that low-cost GPGPU-based hardware systems can be used to accelerate arrhythmia simulations. We ported a two dimensional monodomain cardiac model and executed it on various GPGPU platforms. Electrical activity was simulated during point stimulation and rotor activity. Our GPGPU implementations provided significant speedups over the CPU implementation: 18X for point stimulation and 12X for rotor activity. We found that the number of threads that could be launched concurrently was a critical factor in optimizing the GPGPU implementations.

Entities:  

Mesh:

Year:  2011        PMID: 22254412      PMCID: PMC3589987          DOI: 10.1109/IEMBS.2011.6090164

Source DB:  PubMed          Journal:  Conf Proc IEEE Eng Med Biol Soc        ISSN: 1557-170X


  5 in total

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Authors:  Konstantin Agladze; Matthew W Kay; Valentin Krinsky; Narine Sarvazyan
Journal:  Am J Physiol Heart Circ Physiol       Date:  2007-03-23       Impact factor: 4.733

2.  Reconstruction of the action potential of ventricular myocardial fibres.

Authors:  G W Beeler; H Reuter
Journal:  J Physiol       Date:  1977-06       Impact factor: 5.182

3.  Revised formulation of the Hodgkin-Huxley representation of the sodium current in cardiac cells.

Authors:  J P Drouhard; F A Roberge
Journal:  Comput Biomed Res       Date:  1987-08

4.  Measuring curvature and velocity vector fields for waves of cardiac excitation in 2-D media.

Authors:  Matthew W Kay; Richard A Gray
Journal:  IEEE Trans Biomed Eng       Date:  2005-01       Impact factor: 4.538

5.  Implications of the Turing completeness of reaction-diffusion models, informed by GPGPU simulations on an XBox 360: cardiac arrhythmias, re-entry and the Halting problem.

Authors:  Simon Scarle
Journal:  Comput Biol Chem       Date:  2009-06-11       Impact factor: 2.877

  5 in total
  4 in total

Review 1.  Computational approaches to understand cardiac electrophysiology and arrhythmias.

Authors:  Byron N Roberts; Pei-Chi Yang; Steven B Behrens; Jonathan D Moreno; Colleen E Clancy
Journal:  Am J Physiol Heart Circ Physiol       Date:  2012-08-10       Impact factor: 4.733

2.  Atrial fibrillation driver identification through regional mutual information networks: a modeling perspective.

Authors:  Qun Sha; Luizetta Elliott; Xiangming Zhang; Tzachi Levy; Tushar Sharma; Ahmed Abdelaal
Journal:  J Interv Card Electrophysiol       Date:  2022-01-04       Impact factor: 1.759

3.  Fast acceleration of 2D wave propagation simulations using modern computational accelerators.

Authors:  Wei Wang; Lifan Xu; John Cavazos; Howie H Huang; Matthew Kay
Journal:  PLoS One       Date:  2014-01-30       Impact factor: 3.240

Review 4.  A Heart for Diversity: Simulating Variability in Cardiac Arrhythmia Research.

Authors:  Haibo Ni; Stefano Morotti; Eleonora Grandi
Journal:  Front Physiol       Date:  2018-07-20       Impact factor: 4.566

  4 in total

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