Development of an implantable microstimulation system for chronic DBS in rodents.

High frequency deep brain stimulation (DBS) of certain basal ganglia nuclei (e.g. subthalamic nucleus, STN) has emerged as a powerful neuromodulatory approach in the treatment of late stage Parkinson's disease patients. However, the underlying mechanisms of action are not fully understood. We have therefore established an implantable DBS device for small laboratory animals (e.g. rats) that allows the reliable and safe application of continuous DBS for at least 3 weeks. We could further show that miniaturized monopolar electrodes comprising activated iridium are suitable for continuous stimulation of small brain structures like the STN without inducing severe insertion or stimulation related injuries.