AIMS: The aim of the current study was to assess cardiac structure and function as well as cardiac abnormalities in a large patient-population based multicenter study of HIV-infected subjects. MATERIALS AND METHODS: We enrolled 803 HIV-positive adults (83.4% men, mean age: 44.2 ± 10.3 yrs) in this prospective, cross-sectional cohort study. The study protocol included a standardized documentation of patient history, medical treatment and clinical examination. All subjects underwent a standardized transthoracic echocardiographic examination protocol including Doppler and tissue Doppler imaging. RESULTS: Echocardiographic measurements revealed a structural dilatation of the left ventricle in 10.1% of all HIV-infected subjects. Interventricular septum and posterior wall thickness were increased in 18.0% and 11.1%, respectively, with elevated muscle mass in 14.3% male and 19.4% female patients. Of all participants 13.5% exhibited a pathologic contraction characteristic of one or more myocardial segments. Prevalence of systolic and diastolic dysfunction was 34.3% and 48.0%, respectively. However, severe forms of ventricular dysfunction were rare. CONCLUSIONS: In conclusion our results demonstrate the relevance of echocardiography in this patient-population in the era of antiretroviral therapy. Above all, left ventricular wall thickness and function should be controlled regularly in HIV-infected subjects. (ClinicalTrials.gov number, NCT01119729).
AIMS: The aim of the current study was to assess cardiac structure and function as well as cardiac abnormalities in a large patient-population based multicenter study of HIV-infected subjects. MATERIALS AND METHODS: We enrolled 803 HIV-positive adults (83.4% men, mean age: 44.2 ± 10.3 yrs) in this prospective, cross-sectional cohort study. The study protocol included a standardized documentation of patient history, medical treatment and clinical examination. All subjects underwent a standardized transthoracic echocardiographic examination protocol including Doppler and tissue Doppler imaging. RESULTS: Echocardiographic measurements revealed a structural dilatation of the left ventricle in 10.1% of all HIV-infected subjects. Interventricular septum and posterior wall thickness were increased in 18.0% and 11.1%, respectively, with elevated muscle mass in 14.3% male and 19.4% female patients. Of all participants 13.5% exhibited a pathologic contraction characteristic of one or more myocardial segments. Prevalence of systolic and diastolic dysfunction was 34.3% and 48.0%, respectively. However, severe forms of ventricular dysfunction were rare. CONCLUSIONS: In conclusion our results demonstrate the relevance of echocardiography in this patient-population in the era of antiretroviral therapy. Above all, left ventricular wall thickness and function should be controlled regularly in HIV-infected subjects. (ClinicalTrials.gov number, NCT01119729).
Authors: F Bonnet; P Morlat; G Chêne; P Mercié; D Neau; I Chossat; M Decoin; F Djossou; J Beylot; F Dabis Journal: HIV Med Date: 2002-07 Impact factor: 3.180
Authors: Francesca J Torriani; Lauren Komarow; Robert A Parker; Bruno R Cotter; Judith S Currier; Michael P Dubé; Carl J Fichtenbaum; Mariana Gerschenson; Carol K C Mitchell; Robert L Murphy; Kathleen Squires; James H Stein Journal: J Am Coll Cardiol Date: 2008-08-12 Impact factor: 24.094
Authors: Till Neumann; Stefan Esser; Anja Potthoff; Sabine Pankuweit; Anja Neumann; Frank Breuckmann; Katrin Neuhaus; Jana Kondratieva; Thomas Buck; Thomas Müller-Tasch; Rolf Wachter; Christiane Prettin; Götz Gelbrich; Wolfgang Herzog; Burkert Pieske; Mathias Rauchhaus; Markus Löffler; Bernhard Maisch; Andreas Mügge; Jürgen Wasem; Guido Gerken; Norbert H Brockmeyer; Raimund Erbel Journal: Eur J Med Res Date: 2007-06-27 Impact factor: 2.175
Authors: Walter J Paulus; Carsten Tschöpe; John E Sanderson; Cesare Rusconi; Frank A Flachskampf; Frank E Rademakers; Paolo Marino; Otto A Smiseth; Gilles De Keulenaer; Adelino F Leite-Moreira; Attila Borbély; István Edes; Martin Louis Handoko; Stephane Heymans; Natalia Pezzali; Burkert Pieske; Kenneth Dickstein; Alan G Fraser; Dirk L Brutsaert Journal: Eur Heart J Date: 2007-04-11 Impact factor: 29.983
Authors: Thomas J Starc; Steven E Lipshultz; Kirk A Easley; Samuel Kaplan; J Timothy Bricker; Steven D Colan; Wyman W Lai; Welton M Gersony; George Sopko; Douglas S Moodie; Mark D Schluchter Journal: J Pediatr Date: 2002-09 Impact factor: 4.406
Authors: W Todd Cade; Alan D Waggoner; Sara Hubert; Melissa J Krauss; Gautam K Singh; E Turner Overton Journal: AIDS Date: 2012-10-23 Impact factor: 4.177
Authors: Diana K Thiara; Chia Ying Liu; Fabio Raman; Sabrina Mangat; Julia B Purdy; Horacio A Duarte; Nancyanne Schmidt; Jamie Hur; Christopher T Sibley; David A Bluemke; Colleen Hadigan Journal: J Infect Dis Date: 2015-05-11 Impact factor: 5.226
Authors: Matthew S Freiberg; Chung-Chou H Chang; Melissa Skanderson; Olga V Patterson; Scott L DuVall; Cynthia A Brandt; Kaku A So-Armah; Ramachandran S Vasan; Kris Ann Oursler; John Gottdiener; Stephen Gottlieb; David Leaf; Maria Rodriguez-Barradas; Russell P Tracy; Cynthia L Gibert; David Rimland; Roger J Bedimo; Sheldon T Brown; Matthew Bidwell Goetz; Alberta Warner; Kristina Crothers; Hilary A Tindle; Charles Alcorn; Justin M Bachmann; Amy C Justice; Adeel A Butt Journal: JAMA Cardiol Date: 2017-05-01 Impact factor: 14.676
Authors: William Todd Cade; Edgar Turner Overton; Kristin Mondy; Lisa de las Fuentes; Victor G Davila-Roman; Alan D Waggoner; Dominic N Reeds; Sherry Lassa-Claxton; Melissa J Krauss; Linda R Peterson; Kevin E Yarasheski Journal: AIDS Res Hum Retroviruses Date: 2013-05-06 Impact factor: 2.205
Authors: Steven E Lipshultz; Nao Sasaki; Bruce Thompson; Benjamin W Eidem; Irene Cheng; Steven D Colan; Sharon E O'Brien; Shahnawaz Amdani; William T Shearer; Endel John Orav; Tracie L Miller; James D Wilkinson Journal: AIDS Date: 2020-03-15 Impact factor: 4.177