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Literature DB >> 22253261

LRRK2 and human disease: a complicated question or a question of complexes?

Abstract

Leucine-rich repeat kinase 2 (LRRK2) is linked to various diseases, including Parkinson's disease, cancer, and leprosy. Data from LRRK2 knockout mice has highlighted a possible role for LRRK2 in regulating signaling pathways that are linked to the pathogenesis of Crohn's disease. Here, we examine how LRRK2's role as a signaling hub in the cell could lead to diverse pathologies.

Entities: Chemical

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Year: 2012 PMID： 22253261 DOI： 10.1126/scisignal.2002680

Source DB: PubMed Journal: Sci Signal ISSN： 1945-0877 Impact factor: 8.192

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Cited

32 in total

1. Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice.

Authors: M Yue; K M Hinkle; P Davies; E Trushina; F C Fiesel; T A Christenson; A S Schroeder; L Zhang; E Bowles; B Behrouz; S J Lincoln; J E Beevers; A J Milnerwood; A Kurti; P J McLean; J D Fryer; W Springer; D W Dickson; M J Farrer; H L Melrose
Journal: Neurobiol Dis Date: 2015-03-31 Impact factor: 5.996

Review 2. Evolution of neurodegeneration.

Authors: Mark R Cookson
Journal: Curr Biol Date: 2012-09-11 Impact factor: 10.834

3. High-Resolution Melting Analysis as a Developed Method for Genotyping the PD Susceptibility Loci in LRRK2 Gene.

Authors: Enzhu Jiang; Fengrui Li; Chenchen Jing; Pei Li; Honggang Cui; Baojie Wang; Mei Ding; Hao Pang
Journal: J Clin Lab Anal Date: 2014-05-21 Impact factor: 2.352

4. Mutant LRRK2 toxicity in neurons depends on LRRK2 levels and synuclein but not kinase activity or inclusion bodies.

Authors: Gaia Skibinski; Ken Nakamura; Mark R Cookson; Steven Finkbeiner
Journal: J Neurosci Date: 2014-01-08 Impact factor: 6.167

5. Association of the LRRK2 genetic polymorphisms with leprosy in Han Chinese from Southwest China.

Authors: D Wang; L Xu; L Lv; L-Y Su; Y Fan; D-F Zhang; R Bi; D Yu; W Zhang; X-A Li; Y-Y Li; Y-G Yao
Journal: Genes Immun Date: 2014-12-18 Impact factor: 2.676

Review 6. Current understanding of LRRK2 in Parkinson's disease: biochemical and structural features and inhibitor design.

Authors: Soumya Ray; Min Liu
Journal: Future Med Chem Date: 2012-09 Impact factor: 3.808

LRRK2 and human disease: a complicated question or a question of complexes?

1. Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice.

Review 2. Evolution of neurodegeneration.

3. High-Resolution Melting Analysis as a Developed Method for Genotyping the PD Susceptibility Loci in LRRK2 Gene.

4. Mutant LRRK2 toxicity in neurons depends on LRRK2 levels and synuclein but not kinase activity or inclusion bodies.

5. Association of the LRRK2 genetic polymorphisms with leprosy in Han Chinese from Southwest China.

Review 6. Current understanding of LRRK2 in Parkinson's disease: biochemical and structural features and inhibitor design.

Review 7. Recent advances in Parkinson’s disease genetics.

8. In silico comparative analysis of LRRK2 interactomes from brain, kidney and lung.

9. LRRK2: an éminence grise of Wnt-mediated neurogenesis?

10. A Link between Autophagy and the Pathophysiology of LRRK2 in Parkinson's Disease.