Literature DB >> 22252800

Tolerability and safety of primaquine in Papua New Guinean children 1 to 10 years of age.

Inoni Betuela1, Quique Bassat, Benson Kiniboro, Leanne J Robinson, Anna Rosanas-Urgell, Danielle Stanisic, Peter M Siba, Pedro L Alonso, Ivo Mueller.   

Abstract

Primaquine is currently the only drug available for radical cure of Plasmodium vivax and P. ovale liver infection stages, but limited safety data exist for children <10 years of age. Detailed daily assessments of side effects in glucose-6-phosphate dehydrogenase (G6PD)-normal children treated with 14 days of primaquine plus chloroquine (3 days; n = 252) or artesunate (7 days; n = 141) (0.5 mg/kg of body weight) showed that both treatments are well tolerated, do not lead to reductions in hemoglobin levels, and can thus safely be used in children 1 to 10 years of age.

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Year:  2012        PMID： 22252800      PMCID： PMC3318393          DOI： 10.1128/AAC.05566-11

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  11 in total

1.  Toxicity of primaquine in Caucasians.

Authors:  C B CLAYMAN; J ARNOLD; R S HOCKWALD; E H YOUNT; J H EDGCOMB; A S ALVING
Journal:  J Am Med Assoc       Date:  1952-08-23

2.  In Tanzania, hemolysis after a single dose of primaquine coadministered with an artemisinin is not restricted to glucose-6-phosphate dehydrogenase-deficient (G6PD A-) individuals.

Authors:  Seif A Shekalaghe; Roel ter Braak; Modibo Daou; Reginald Kavishe; Wouter van den Bijllaardt; Sven van den Bosch; Jan B Koenderink; Adrian J F Luty; Christopher J M Whitty; Chris Drakeley; Robert W Sauerwein; Teun Bousema
Journal:  Antimicrob Agents Chemother       Date:  2010-03-01       Impact factor: 5.191

Review 3.  Primaquine therapy for malaria.

Authors:  J Kevin Baird; Stephen L Hoffman
Journal:  Clin Infect Dis       Date:  2004-10-12       Impact factor: 9.079

4.  Can primaquine therapy for vivax malaria be improved?

Authors:  J Kevin Baird; Karl H Rieckmann
Journal:  Trends Parasitol       Date:  2003-03

5.  Differential patterns of infection and disease with P. falciparum and P. vivax in young Papua New Guinean children.

Authors:  Enmoore Lin; Benson Kiniboro; Laurie Gray; Stuart Dobbie; Leanne Robinson; Annemarie Laumaea; Sonja Schöpflin; Danielle Stanisic; Inoni Betuela; Melinda Blood-Zikursh; Peter Siba; Ingrid Felger; Louis Schofield; Peter Zimmerman; Ivo Mueller
Journal:  PLoS One       Date:  2010-02-04       Impact factor: 3.240

Review 6.  Glucose-6-phosphate dehydrogenase deficiency.

Authors:  M D Cappellini; G Fiorelli
Journal:  Lancet       Date:  2008-01-05       Impact factor: 79.321

Review 7.  Medications and glucose-6-phosphate dehydrogenase deficiency: an evidence-based review.

Authors:  Ilan Youngster; Lidia Arcavi; Renata Schechmaster; Yulia Akayzen; Hen Popliski; Janna Shimonov; Svetlana Beig; Matitiahu Berkovitch
Journal:  Drug Saf       Date:  2010-09-01       Impact factor: 5.228

8.  Malaria morbidity in Papua Indonesia, an area with multidrug resistant Plasmodium vivax and Plasmodium falciparum.

Authors:  Muhammad Karyana; Lenny Burdarm; Shunmay Yeung; Enny Kenangalem; Noah Wariker; Rilia Maristela; Ketut Gde Umana; Ram Vemuri; Maurits J Okoseray; Pasi M Penttinen; Peter Ebsworth; Paulus Sugiarto; Nicholas M Anstey; Emiliana Tjitra; Richard N Price
Journal:  Malar J       Date:  2008-08-02       Impact factor: 2.979

9.  High sensitivity detection of Plasmodium species reveals positive correlations between infections of different species, shifts in age distribution and reduced local variation in Papua New Guinea.

Authors:  Ivo Mueller; Simone Widmer; Daniela Michel; Seri Maraga; David T McNamara; Benson Kiniboro; Albert Sie; Thomas A Smith; Peter A Zimmerman
Journal:  Malar J       Date:  2009-03-11       Impact factor: 2.979

10.  Plasmodium vivax and mixed infections are associated with severe malaria in children: a prospective cohort study from Papua New Guinea.

Authors:  Blaise Genton; Valérie D'Acremont; Lawrence Rare; Kay Baea; John C Reeder; Michael P Alpers; Ivo Müller
Journal:  PLoS Med       Date:  2008-06-17       Impact factor: 11.069
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  10 in total

1.  Trade-off between tolerance and resistance to infections: an experimental approach with malaria parasites in a passerine bird.

Authors:  Elena Arriero; Javier Pérez-Tris; Alvaro Ramírez; Carolina Remacha
Journal:  Oecologia       Date:  2018-10-30       Impact factor: 3.225

2.  Pharmacokinetic properties of single-dose primaquine in Papua New Guinean children: feasibility of abbreviated high-dose regimens for radical cure of vivax malaria.

Authors:  Brioni R Moore; Sam Salman; John Benjamin; Madhu Page-Sharp; Leanne J Robinson; Elizabeth Waita; Kevin T Batty; Peter Siba; Ivo Mueller; Timothy M E Davis; Inoni Betuela
Journal:  Antimicrob Agents Chemother       Date:  2013-11-04       Impact factor: 5.191

3.  Safety of single low-dose primaquine in glucose-6-phosphate dehydrogenase deficient falciparum-infected African males: Two open-label, randomized, safety trials.

Authors:  Guido J H Bastiaens; Alfred B Tiono; Joseph Okebe; Helmi E Pett; Sam A Coulibaly; Bronner P Gonçalves; Muna Affara; Alphonse Ouédraogo; Edith C Bougouma; Guillaume S Sanou; Issa Nébié; John Bradley; Kjerstin H W Lanke; Mikko Niemi; Sodiomon B Sirima; Umberto d'Alessandro; Teun Bousema; Chris Drakeley
Journal:  PLoS One       Date:  2018-01-11       Impact factor: 3.240

4.  Primaquine Pharmacokinetics in Lactating Women and Breastfed Infant Exposures.

Authors:  Mary Ellen Gilder; Warunee Hanpithakphong; Richard M Hoglund; Joel Tarning; Htun Htun Win; Naw Hilda; Cindy S Chu; Germana Bancone; Verena I Carrara; Pratap Singhasivanon; Nicholas J White; François Nosten; Rose McGready
Journal:  Clin Infect Dis       Date:  2018-09-14       Impact factor: 9.079

5.  Primaquine at alternative dosing schedules for preventing relapse in people with Plasmodium vivax malaria.

Authors:  Rachael Milligan; André Daher; Patricia M Graves
Journal:  Cochrane Database Syst Rev       Date:  2019-07-05

6.  Severe Plasmodium vivax malaria among sudanese children at New Halfa Hospital, Eastern Sudan.

Authors:  Hyder Mahgoub; Gasim I Gasim; Imad R Musa; Ishag Adam
Journal:  Parasit Vectors       Date:  2012-07-30       Impact factor: 3.876

Review 7.  Management of imported malaria in Europe.

Authors:  Helena H Askling; Fabrice Bruneel; Gerd Burchard; Francesco Castelli; Peter L Chiodini; Martin P Grobusch; Rogelio Lopez-Vélez; Margaret Paul; Eskild Petersen; Corneliu Popescu; Michael Ramharter; Patricia Schlagenhauf
Journal:  Malar J       Date:  2012-09-17       Impact factor: 2.979

8.  Strategies for understanding and reducing the Plasmodium vivax and Plasmodium ovale hypnozoite reservoir in Papua New Guinean children: a randomised placebo-controlled trial and mathematical model.

Authors:  Leanne J Robinson; Rahel Wampfler; Inoni Betuela; Stephan Karl; Michael T White; Connie S N Li Wai Suen; Natalie E Hofmann; Benson Kinboro; Andreea Waltmann; Jessica Brewster; Lina Lorry; Nandao Tarongka; Lornah Samol; Mariabeth Silkey; Quique Bassat; Peter M Siba; Louis Schofield; Ingrid Felger; Ivo Mueller
Journal:  PLoS Med       Date:  2015-10-27       Impact factor: 11.069

9.  Safety of 8-aminoquinolines given to people with G6PD deficiency: protocol for systematic review of prospective studies.

Authors:  Olalekan A Uthman; Rachel Saunders; David Sinclair; Patricia Graves; Hellen Gelband; Aileen Clarke; Paul Garner
Journal:  BMJ Open       Date:  2014-05-14       Impact factor: 2.692

10.  Development of weight and age-based dosing of daily primaquine for radical cure of vivax malaria.

Authors:  Joel Tarning; Mavuto Mukaka; Walter Robert Taylor; Richard M Hoglund; Pimnara Peerawaranun; Thuy Nhien Nguyen; Tran Tinh Hien; Arnaud Tarantola; Lorenz von Seidlein; Rupam Tripura; Thomas J Peto; Arjen M Dondorp; Jordi Landier; Francois H Nosten; Frank Smithuis; Koukeo Phommasone; Mayfong Mayxay; Soy Ty Kheang; Chy Say; Kak Neeraj; Leang Rithea; Lek Dysoley; Sim Kheng; Sinoun Muth; Arantxa Roca-Feltrer; Mark Debackere; Rick M Fairhurst; Ngak Song; Philippe Buchy; Didier Menard; Nicholas J White
Journal:  Malar J       Date:  2021-09-09       Impact factor: 2.979
  10 in total

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