OBJECTIVES: To describe change in subgroups characterized by patterns of depression, anxiety, and functional impairment; examine treatment effects on subgroup membership; examine effects of sex and age on subgroup membership. METHODS: Latent class models were used to meet the first 2 objectives using 79 patients with depression/anxiety. Generalized estimating equations were used to meet the third objective. RESULTS: Three subgroups characterized by different combinations of psychiatric disorders and functioning were identified. Patients who received treatment were more likely to transition to a less impaired subgroup. CONCLUSIONS: Unique information about holistic treatment effects can be gained when multiple outcomes are considered simultaneously.
RCT Entities:
OBJECTIVES: To describe change in subgroups characterized by patterns of depression, anxiety, and functional impairment; examine treatment effects on subgroup membership; examine effects of sex and age on subgroup membership. METHODS: Latent class models were used to meet the first 2 objectives using 79 patients with depression/anxiety. Generalized estimating equations were used to meet the third objective. RESULTS: Three subgroups characterized by different combinations of psychiatric disorders and functioning were identified. Patients who received treatment were more likely to transition to a less impaired subgroup. CONCLUSIONS: Unique information about holistic treatment effects can be gained when multiple outcomes are considered simultaneously.
Authors: Neil Schneiderman; Patrice G Saab; Diane J Catellier; Lynda H Powell; Robert F DeBusk; Redford B Williams; Robert M Carney; James M Raczynski; Marie J Cowan; Lisa F Berkman; Peter G Kaufmann Journal: Psychosom Med Date: 2004 Jul-Aug Impact factor: 4.312
Authors: J C Barefoot; M J Helms; D B Mark; J A Blumenthal; R M Califf; T L Haney; C M O'Connor; I C Siegler; R B Williams Journal: Am J Cardiol Date: 1996-09-15 Impact factor: 2.778
Authors: Lisa F Berkman; James Blumenthal; Matthew Burg; Robert M Carney; Diane Catellier; Marie J Cowan; Susan M Czajkowski; Robert DeBusk; James Hosking; Allan Jaffe; Peter G Kaufmann; Pamela Mitchell; James Norman; Lynda H Powell; James M Raczynski; Neil Schneiderman Journal: JAMA Date: 2003-06-18 Impact factor: 56.272
Authors: Robert J Goldberg; Jane S Saczynski; David D McManus; Molly E Waring; Richard McManus; Jeroan Allison; David C Parish; Darleen Lessard; Sharina Person; Joel M Gore; Catarina I Kiefe Journal: Am J Med Date: 2015-05-23 Impact factor: 4.965