AIMS: Angioimmunoblastic T-cell lymphoma (AITL) may present in patterns 1, 2 or 3, representing those with hyperplastic, regressed or effaced germinal centres (GCs), respectively, but the prognostic utility of this subclassification has not been previously validated. METHODS AND RESULTS: Twenty-five cases of AITL were reviewed immunohistologically and with in-situ hybridization for Epstein-Barr virus-encoded RNA and polymerase chain reaction for T-cell receptor gamma and immunoglobulin heavy chain clonality and followed for up to 120 months. Four cases had conventional hyperplastic GCs, two had floral GCs, and one had progressively transformed GCs, consistent with pattern 1 and one additional case had hyalinized GCs, consistent with pattern 2. The remaining 17 (pattern 3) cases lacked morphologically discernible GCs. The Kaplan-Meier survival distribution of pattern 1 cases (5-year survival 83%) was superior to that of pattern 2 and 3 cases [5-year-survival 36% (P = 0.0417)] only when combined with the 31 cases, seven of which were pattern 1, that Attygalle et al. had followed for up to 247 months and previously published. Furthermore, the development of B-lineage (classical Hodgkin or diffuse large-cell) lymphoma was associated exclusively with pattern 3 (P = 0.0057). CONCLUSIONS: Pattern 1 represents an indolent phase/grade of AITL, unassociated with the development of secondary B-lineage lymphoma and uninfluenced by treatment regimen.
AIMS: Angioimmunoblastic T-cell lymphoma (AITL) may present in patterns 1, 2 or 3, representing those with hyperplastic, regressed or effaced germinal centres (GCs), respectively, but the prognostic utility of this subclassification has not been previously validated. METHODS AND RESULTS: Twenty-five cases of AITL were reviewed immunohistologically and with in-situ hybridization for Epstein-Barr virus-encoded RNA and polymerase chain reaction for T-cell receptor gamma and immunoglobulin heavy chain clonality and followed for up to 120 months. Four cases had conventional hyperplastic GCs, two had floral GCs, and one had progressively transformed GCs, consistent with pattern 1 and one additional case had hyalinized GCs, consistent with pattern 2. The remaining 17 (pattern 3) cases lacked morphologically discernible GCs. The Kaplan-Meier survival distribution of pattern 1 cases (5-year survival 83%) was superior to that of pattern 2 and 3 cases [5-year-survival 36% (P = 0.0417)] only when combined with the 31 cases, seven of which were pattern 1, that Attygalle et al. had followed for up to 247 months and previously published. Furthermore, the development of B-lineage (classical Hodgkin or diffuse large-cell) lymphoma was associated exclusively with pattern 3 (P = 0.0057). CONCLUSIONS: Pattern 1 represents an indolent phase/grade of AITL, unassociated with the development of secondary B-lineage lymphoma and uninfluenced by treatment regimen.
Authors: Marta Rodríguez; Ruth Alonso-Alonso; Laura Tomás-Roca; Socorro M Rodríguez-Pinilla; Rebeca Manso-Alonso; Laura Cereceda; Jennifer Borregón; Teresa Villaescusa; Raúl Córdoba; Margarita Sánchez-Beato; Ismael Fernández-Miranda; Isabel Betancor; Carmen Bárcena; Juan F García; Manuela Mollejo; Mónica García-Cosio; Paloma Martin-Acosta; Fina Climent; Dolores Caballero; Lorena de la Fuente; Pablo Mínguez; Linda Kessler; Catherine Scholz; Antonio Gualberto; Rufino Mondéjar; Miguel A Piris Journal: Blood Adv Date: 2021-12-28
Authors: Rachel Dobson; Peter Y Du; Lívia Rásó-Barnett; Wen-Qing Yao; Zi Chen; Calogero Casa; Hesham Ei-Daly; Lorant Farkas; Elizabeth Soilleux; Penny Wright; John W Grant; Manuel Rodriguez-Justo; George A Follows; Hala Rashed; Margarete Fabre; E Joanna Baxter; George Vassiliou; Andrew Wotherspoon; Ayoma D Attygalle; Hongxiang Liu; Ming-Qing Du Journal: Haematologica Date: 2022-02-01 Impact factor: 9.941