OBJECTIVES: To examine the association of genetic variants in the syntaxin 1A gene (STX1A) with common forms of migraine, and perform a combined analysis of the data from the current study and previously published reports. METHODS: We investigated the parent-to-offspring transmission of rs6951030, rs4363087 and rs2293489 in 191 family trios, each with a proband with childhood-onset migraine, and performed a case-control analysis between the probands and 223 unrelated controls. In addition, we performed a combined data analysis with an overall sample of 567 migraine patients and 720 unrelated controls and performed a migraine-specific gene-network analysis. RESULTS: The transmission disequilibrium test revealed significant transmission distortion of rs4363087 in migraine overall (OR = 1.56, p = 0.006; p = 0.01 after correction for multiple testing) and migraine without aura (OR = 1.58, p = 0.01; corrected p = 0.04). Two-marker haplotype analysis revealed transmission distortion of A-G (rs6951030-rs4363087; OR = 1.47, p = 0.01) and A-C (rs4363087-rs2293489; OR = 0.66, p = 0.01). Combined analysis showed significant association of rs941298 with migraine overall (OR = 1.28, p = 0.004) and migraine without aura (OR = 1.3, p = 0.008). Network analysis identified 24 genes relating STX1A to other migraine candidate genes, including KCNK18 (TRESK channel) involved in the cytoplasmatic calcium signalling together with syntaxin 1A. CONCLUSION: Our results provide support for the hypothesis that STX1A represents a susceptibility gene for migraine.
OBJECTIVES: To examine the association of genetic variants in the syntaxin 1A gene (STX1A) with common forms of migraine, and perform a combined analysis of the data from the current study and previously published reports. METHODS: We investigated the parent-to-offspring transmission of rs6951030, rs4363087 and rs2293489 in 191 family trios, each with a proband with childhood-onset migraine, and performed a case-control analysis between the probands and 223 unrelated controls. In addition, we performed a combined data analysis with an overall sample of 567 migrainepatients and 720 unrelated controls and performed a migraine-specific gene-network analysis. RESULTS: The transmission disequilibrium test revealed significant transmission distortion of rs4363087 in migraine overall (OR = 1.56, p = 0.006; p = 0.01 after correction for multiple testing) and migraine without aura (OR = 1.58, p = 0.01; corrected p = 0.04). Two-marker haplotype analysis revealed transmission distortion of A-G (rs6951030-rs4363087; OR = 1.47, p = 0.01) and A-C (rs4363087-rs2293489; OR = 0.66, p = 0.01). Combined analysis showed significant association of rs941298 with migraine overall (OR = 1.28, p = 0.004) and migraine without aura (OR = 1.3, p = 0.008). Network analysis identified 24 genes relating STX1A to other migraine candidate genes, including KCNK18 (TRESK channel) involved in the cytoplasmatic calcium signalling together with syntaxin 1A. CONCLUSION: Our results provide support for the hypothesis that STX1A represents a susceptibility gene for migraine.
Authors: Katharina Eikermann-Haerter; Michal Arbel-Ornath; Nilufer Yalcin; Esther S Yu; Kishore V Kuchibhotla; Izumi Yuzawa; Eloise Hudry; Carli R Willard; Mihail Climov; Fatmagul Keles; Arianna M Belcher; Buse Sengul; Andrea Negro; Isaac A Rosen; Andrea Arreguin; Michel D Ferrari; Arn M J M van den Maagdenberg; Brian J Bacskai; Cenk Ayata Journal: Ann Neurol Date: 2015-07-06 Impact factor: 10.422
Authors: Franca R Guerini; Enrico Ripamonti; Andrea S Costa; Milena Zanzottera; Cristina Agliardi; Elisabetta Bolognesi; Mario Clerici; Vittorio Racca Journal: Medicine (Baltimore) Date: 2019-06 Impact factor: 1.889
Authors: Giulia Spoto; Giulia Valentini; Maria Concetta Saia; Ambra Butera; Greta Amore; Vincenzo Salpietro; Antonio Gennaro Nicotera; Gabriella Di Rosa Journal: Front Neurol Date: 2022-03-08 Impact factor: 4.003