| Literature DB >> 22248059 |
B Bonavida1, S Huerta-Yepez, S Baritaki, M Vega, H Liu, H Chen, J Berenson.
Abstract
The transcription factor Yin Yang (YY) 1 has been reported to be overexpressed in several tumor types and plays a role in both the progression of the disease as well as the maintenance of tumor cell resistance to cell death by cytotoxic drugs. YY1 also has been reported to be a prognostic factor for several cancers and was proposed to be a therapeutic target. The expression, function, and role of YY1 in the pathogenesis of hematologic malignancies are summarized briefly herein. Data are represented for B non-Hodgkin lymphoma, AIDS-related lymphoma, multiple myeloma, and children's acute lymphocytic leukemia.Entities:
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Year: 2011 PMID： 22248059 DOI： 10.1615/critrevoncog.v16.i3-4.90
Source DB: PubMed Journal: Crit Rev Oncog ISSN： 0893-9675