OBJECTIVE: Two reported genetic polymorphisms related to the production of brain-derived neurotrophic factor (BNDF) and reuptake by the serotonin transporter (5-HTT) appear to contribute to depression in combination with stressful life events. The aim of the current study was to investigate the contribution of early life stress (ELS), BDNF (Val versus Met alleles) and 5-HTT polymorphisms (L versus S alleles) to melancholic (n = 65) and non-melancholic depression (n = 59). METHODS: A mediation approach ((G × G) × E mediation model) was employed to confirm the indirect effects of ELS on the relationship between 5-HTTPLR × BDNF polymorphism combinations and depression subtype. A series of binary logistic regressions were then conducted to determine whether genotype, ELS, and their interaction were able to predict depression subtype. RESULTS: Key findings indicated that BDNF and 5-HTT polymorphisms in combination with ELS contributed to the development of non-melancholic depression. An interaction between BDNF and ELS increased the risk of non-melancholia by 3.327, whereas the interaction between 5-HTT and ELS increased risk by 2.406. CONCLUSION: The results support a role for genetic factors in the development of non-melancholia. The lack of findings in melancholia indicates that other mechanisms may underlie the subtype. Alternatively, null findings may reflect a Type II error associated with a small sample size. Future studies should consider further examination of differential gene-environment interactions for melancholia versus non-melancholia.
OBJECTIVE: Two reported genetic polymorphisms related to the production of brain-derived neurotrophic factor (BNDF) and reuptake by the serotonin transporter (5-HTT) appear to contribute to depression in combination with stressful life events. The aim of the current study was to investigate the contribution of early life stress (ELS), BDNF (Val versus Met alleles) and 5-HTT polymorphisms (L versus S alleles) to melancholic (n = 65) and non-melancholic depression (n = 59). METHODS: A mediation approach ((G × G) × E mediation model) was employed to confirm the indirect effects of ELS on the relationship between 5-HTTPLR × BDNF polymorphism combinations and depression subtype. A series of binary logistic regressions were then conducted to determine whether genotype, ELS, and their interaction were able to predict depression subtype. RESULTS: Key findings indicated that BDNF and 5-HTT polymorphisms in combination with ELS contributed to the development of non-melancholic depression. An interaction between BDNF and ELS increased the risk of non-melancholia by 3.327, whereas the interaction between 5-HTT and ELS increased risk by 2.406. CONCLUSION: The results support a role for genetic factors in the development of non-melancholia. The lack of findings in melancholia indicates that other mechanisms may underlie the subtype. Alternatively, null findings may reflect a Type II error associated with a small sample size. Future studies should consider further examination of differential gene-environment interactions for melancholia versus non-melancholia.
Authors: Blanca Gutiérrez; Juan Á Bellón; Margarita Rivera; Esther Molina; Michael King; Louise Marston; Francisco Torres-González; Berta Moreno-Küstner; Patricia Moreno-Peral; Emma Motrico; Carmen Montón-Franco; María J GildeGómez-Barragán; Marta Sánchez-Celaya; Miguel Á Díaz-Barreiros; Catalina Vicens; Juan de Dios Luna; Irwin Nazareth; Jorge Cervilla Journal: J Psychiatry Neurosci Date: 2015-05 Impact factor: 6.186
Authors: Joseph P Gyekis; Weihong Yu; Shuqian Dong; Haina Wang; Jun Qian; Pravina Kota; Jingyun Yang Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2012-11-26 Impact factor: 3.568
Authors: Matthew Owens; Ian M Goodyer; Paul Wilkinson; Anupam Bhardwaj; Rosemary Abbott; Tim Croudace; Valerie Dunn; Peter B Jones; Nicholas D Walsh; Maria Ban; Barbara J Sahakian Journal: PLoS One Date: 2012-11-28 Impact factor: 3.240
Authors: Tim Outhred; Pritha Das; Carol Dobson-Stone; Kristi Griffiths; Kim L Felmingham; Richard A Bryant; Gin Malhi; Andrew H Kemp Journal: Brain Behav Date: 2012-10-03 Impact factor: 2.708