BACKGROUND: The aim was to prove the effectiveness and safety of faecal bacteriotherapy in the treatment of relapsing pseudomembranous colitis due to Clostridium difficile in clinical practice. METHODS: The protocol of faecal bacteriotherapy was adopted from foreign authors (Bakken JS, Aas J, MacConnachie AA). After six months, the success rate was not satisfying and the method was modified so that 40-50 g of stool were administered instead of 20-30 g. RESULTS: A total of 77.8 % of patients included in the study were successfully treated. The study achieved results comparable with foreign literature where the lowest success rate is about 80 %. Neither complications nor death were noticed (0 % mortality rate). CONCLUSIONS: Faecal bacteriotherapy is a safe and simple method capable of curing chronically relapsing forms of pseudomembranous colitis.
BACKGROUND: The aim was to prove the effectiveness and safety of faecal bacteriotherapy in the treatment of relapsing pseudomembranous colitis due to Clostridium difficile in clinical practice. METHODS: The protocol of faecal bacteriotherapy was adopted from foreign authors (Bakken JS, Aas J, MacConnachie AA). After six months, the success rate was not satisfying and the method was modified so that 40-50 g of stool were administered instead of 20-30 g. RESULTS: A total of 77.8 % of patients included in the study were successfully treated. The study achieved results comparable with foreign literature where the lowest success rate is about 80 %. Neither complications nor death were noticed (0 % mortality rate). CONCLUSIONS: Faecal bacteriotherapy is a safe and simple method capable of curing chronically relapsing forms of pseudomembranous colitis.
Authors: Alexander Kleger; Jacqueline Schnell; Andreas Essig; Martin Wagner; Martin Bommer; Thomas Seufferlein; Georg Härter Journal: Dtsch Arztebl Int Date: 2013-02-15 Impact factor: 5.594
Authors: Zeina Z Berro; Righab H Hamdan; Israa H Dandache; Mohamad N Saab; Hussein H Karnib; Mahmoud H Younes Journal: BMC Infect Dis Date: 2016-05-27 Impact factor: 3.090