Literature DB >> 22246885

The novel TrkB receptor agonist 7,8-dihydroxyflavone enhances neuromuscular transmission.

Carlos B Mantilla1, Leonid G Ermilov.   

Abstract

Neurotrophin signaling at the neuromuscular junction modulates cholinergic transmission and enhances neuromuscular transmission via the tropomyosin-related kinase receptor subtype B (TrkB).A novel flavonoid, 7,8-dihydroxyflavone (7,8-DHF), selectively activates TrkB receptors. Using TrkB(F616A) mice that are susceptible to specific inhibition of TrkB activity by 1NMPP1, we show that neuromuscular transmission is enhanced by 7,8-DHF (∽32%) via activation of TrkB in diaphragm muscle. The small molecule 7,8-DHF may constitute a novel therapy to improve neuromuscular function.
Copyright © 2011 Wiley Periodicals, Inc.

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Year:  2012        PMID： 22246885      PMCID： PMC3261515          DOI： 10.1002/mus.22295

Source DB:  PubMed          Journal:  Muscle Nerve        ISSN： 0148-639X            Impact factor:   3.217


  20 in total

Review 1.  Neurotrophin-regulated signalling pathways.

Authors:  Louis F Reichardt
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2006-09-29       Impact factor: 6.237

2.  Effect of 7,8-dihydroxyflavone, a small-molecule TrkB agonist, on emotional learning.

Authors:  Raul Andero; Scott A Heldt; Keqiang Ye; Xia Liu; Antonio Armario; Kerry J Ressler
Journal:  Am J Psychiatry       Date:  2010-12-01       Impact factor: 18.112

3.  A phase I/II trial of recombinant methionyl human brain derived neurotrophic factor administered by intrathecal infusion to patients with amyotrophic lateral sclerosis.

Authors:  G Ochs; R D Penn; M York; R Giess; M Beck; J Tonn; J Haigh; E Malta; M Traub; M Sendtner; K V Toyka
Journal:  Amyotroph Lateral Scler Other Motor Neuron Disord       Date:  2000-06

4.  Antioxidant activity of 7,8-dihydroxyflavone provides neuroprotection against glutamate-induced toxicity.

Authors:  Jing Chen; Kao-Wei Chua; Chu C Chua; Hailong Yu; Aijie Pei; Balvin H L Chua; Ronald C Hamdy; Xingshun Xu; Chun-Feng Liu
Journal:  Neurosci Lett       Date:  2011-05-27       Impact factor: 3.046

5.  Fatigue of isolated rat diaphragm: role of impaired neuromuscular transmission.

Authors:  T K Aldrich; A Shander; I Chaudhry; H Nagashima
Journal:  J Appl Physiol (1985)       Date:  1986-09

Review 6.  BDNF and activity-dependent synaptic modulation.

Authors:  Bai Lu
Journal:  Learn Mem       Date:  2003 Mar-Apr       Impact factor: 2.460

7.  The interaction between tropomyosin-related kinase B receptors and presynaptic muscarinic receptors modulates transmitter release in adult rodent motor nerve terminals.

Authors:  Neus Garcia; Marta Tomàs; Manel M Santafé; Nuria Besalduch; Maria A Lanuza; Josep Tomàs
Journal:  J Neurosci       Date:  2010-12-08       Impact factor: 6.167

8.  Impairment of diaphragm muscle force and neuromuscular transmission after normothermic cardiopulmonary bypass: effect of low-dose inhaled CO.

Authors:  Leonid G Ermilov; Juan N Pulido; Fawn W Atchison; Wen-Zhi Zhan; Mark H Ereth; Gary C Sieck; Carlos B Mantilla
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2010-01-20       Impact factor: 3.619

9.  Neurotrophin-4 couples to locally modulated ACh release at the end of neuromuscular synapse maturation.

Authors:  N Garcia; M M Santafe; M Tomas; M A Lanuza; N Besalduch; J Tomas
Journal:  Neurosci Lett       Date:  2009-10-27       Impact factor: 3.046

10.  Neurotrophins improve neuromuscular transmission in the adult rat diaphragm.

Authors:  Carlos B Mantilla; Wen-Zhi Zhan; Gary C Sieck
Journal:  Muscle Nerve       Date:  2004-03       Impact factor: 3.217
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  27 in total

1.  7,8-dihydroxyflavone prevents synaptic loss and memory deficits in a mouse model of Alzheimer's disease.

Authors:  Zhentao Zhang; Xia Liu; Jason P Schroeder; Chi-Bun Chan; Mingke Song; Shan Ping Yu; David Weinshenker; Keqiang Ye
Journal:  Neuropsychopharmacology       Date:  2013-09-11       Impact factor: 7.853

Review 2.  Mechanical properties of respiratory muscles.

Authors:  Gary C Sieck; Leonardo F Ferreira; Michael B Reid; Carlos B Mantilla
Journal:  Compr Physiol       Date:  2013-10       Impact factor: 9.090

3.  Functional impact of diaphragm muscle sarcopenia in both male and female mice.

Authors:  Sarah M Greising; Carlos B Mantilla; Juan S Medina-Martínez; Jessica M Stowe; Gary C Sieck
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2015-05-01       Impact factor: 5.464

4.  Ageing and neurotrophic signalling effects on diaphragm neuromuscular function.

Authors:  Sarah M Greising; Leonid G Ermilov; Gary C Sieck; Carlos B Mantilla
Journal:  J Physiol       Date:  2014-12-01       Impact factor: 5.182

5.  7,8-Dihydroxyflavone improves motor performance and enhances lower motor neuronal survival in a mouse model of amyotrophic lateral sclerosis.

Authors:  Orhan Tansel Korkmaz; Nurgul Aytan; Isabel Carreras; Ji-Kyung Choi; Neil W Kowall; Bruce G Jenkins; Alpaslan Dedeoglu
Journal:  Neurosci Lett       Date:  2014-03-15       Impact factor: 3.046

6.  Role of TrkB kinase activity in aging diaphragm neuromuscular junctions.

Authors:  Sarah M Greising; Jessica M Stowe; Gary C Sieck; Carlos B Mantilla
Journal:  Exp Gerontol       Date:  2015-10-27       Impact factor: 4.032

7.  Biochemical and biophysical investigation of the brain-derived neurotrophic factor mimetic 7,8-dihydroxyflavone in the binding and activation of the TrkB receptor.

Authors:  Xia Liu; Obiamaka Obianyo; Chi Bun Chan; Junjian Huang; Shenghui Xue; Jenny J Yang; Fanxing Zeng; Mark Goodman; Keqiang Ye
Journal:  J Biol Chem       Date:  2014-08-20       Impact factor: 5.157

8.  Small-molecule trkB agonists promote axon regeneration in cut peripheral nerves.

Authors:  Arthur W English; Kevin Liu; Jennifer M Nicolini; Amanda M Mulligan; Keqiang Ye
Journal:  Proc Natl Acad Sci U S A       Date:  2013-09-16       Impact factor: 11.205

9.  Motoneuron BDNF/TrkB signaling enhances functional recovery after cervical spinal cord injury.

Authors:  Carlos B Mantilla; Heather M Gransee; Wen-Zhi Zhan; Gary C Sieck
Journal:  Exp Neurol       Date:  2013-04-10       Impact factor: 5.330

10.  Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's disease.

Authors:  Mali Jiang; Qi Peng; Xia Liu; Jing Jin; Zhipeng Hou; Jiangyang Zhang; Susumu Mori; Christopher A Ross; Keqiang Ye; Wenzhen Duan
Journal:  Hum Mol Genet       Date:  2013-02-27       Impact factor: 6.150
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