Literature DB >> 22246106

Interstrand cross-link of DNA by covalently linking a pair of abasic sites.

Kohei Ichikawa1, Naoshi Kojima, Yu Hirano, Toshie Takebayashi, Keiko Kowata, Yasuo Komatsu.   

Abstract

A pair of apurinic/apyrimidinic sites formed in DNA has been covalently connected with bis(aminooxy) derivatives. The efficacy of the interstrand cross-link is associated with the structural tethering of two aminooxy groups. The interstrand cross-link constructed stable DNA scaffolds for enzyme alignment. This journal is © The Royal Society of Chemistry 2012

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Year:  2012        PMID： 22246106     DOI： 10.1039/c2cc16785a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  7 in total

1.  Synthesis of native-like crosslinked duplex RNA and study of its properties.

Authors:  Kazumitsu Onizuka; Madoka E Hazemi; Justin M Thomas; Leanna R Monteleone; Ken Yamada; Shuhei Imoto; Peter A Beal; Fumi Nagatsugi
Journal:  Bioorg Med Chem       Date:  2017-02-21       Impact factor: 3.641

2.  A novel assay revealed that ribonucleotide reductase is functionally important for interstrand DNA crosslink repair.

Authors:  Naoaki Fujii; Benjamin J Evison; Marcelo L Actis; Akira Inoue
Journal:  Bioorg Med Chem       Date:  2015-09-30       Impact factor: 3.641

3.  A simple, high-yield synthesis of DNA duplexes containing a covalent, thermally cleavable interstrand cross-link at a defined location.

Authors:  Jacqueline Gamboa Varela; Kent S Gates
Journal:  Angew Chem Int Ed Engl       Date:  2015-05-12       Impact factor: 15.336

4.  Synthesis of DNA Duplexes Containing Site-Specific Interstrand Cross-Links via Sequential Reductive Amination Reactions Involving Diamine Linkers and Abasic Sites on Complementary Oligodeoxynucleotides.

Authors:  Kurt Housh; Kent S Gates
Journal:  Chem Res Toxicol       Date:  2021-10-25       Impact factor: 3.739

5.  Function Control of Anti-microRNA Oligonucleotides Using Interstrand Cross-Linked Duplexes.

Authors:  Yasuhiro Mie; Yu Hirano; Keiko Kowata; Akiyoshi Nakamura; Mayu Yasunaga; Yoshihiro Nakajima; Yasuo Komatsu
Journal:  Mol Ther Nucleic Acids       Date:  2017-11-14       Impact factor: 8.886

6.  Promotion of cytoplasmic localization of oligonucleotides by connecting cross-linked duplexes.

Authors:  Yu Hirano; Yasuo Komatsu
Journal:  RSC Adv       Date:  2022-08-30       Impact factor: 4.036

7.  Stable duplex-linked antisense targeting miR-148a inhibits breast cancer cell proliferation.

Authors:  Sho Okumura; Yu Hirano; Yasuo Komatsu
Journal:  Sci Rep       Date:  2021-06-01       Impact factor: 4.379
  7 in total

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