| Literature DB >> 22245082 |
Gang Ding1, Lin Chen, Amandajuan Chen, Xinhui Tian, Xiangdong Chen, Hongwu Zhang, Hong Chen, Xing-Zhong Liu, Yonggang Zhang, Zhong-Mei Zou.
Abstract
Two new cytochalasans, trichalasins C (1) and D (2) together with known cytochalasans aspochalasins D (3), M (4) and P (5) were isolated from one endophytic fungus Trichoderma gamsii inhabiting in traditional medicinal plant Panax notoginseng (BurK.) F.H.Chen. The structures for the new compounds 1 and 2 were determined by NMR and HRESIMS, and their relative configurations were established by analysis of coupling constants and NOESY correlations. Compound 3 displaying inhibitory activity with EC₅₀ value 5.72 μM, whereas the EC₅₀ values for compounds 1, 2 and 4, 5 are more than 40 μM. Crown Copyright ÂEntities:
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Year: 2012 PMID： 22245082 DOI： 10.1016/j.fitote.2011.12.021
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882