| Literature DB >> 22245048 |
Rabiya Majeed1, Mallepally V Reddy, Praveen K Chinthakindi, Payare L Sangwan, Abid Hamid, Gousia Chashoo, Ajit K Saxena, Surrinder Koul.
Abstract
A library of 28 compounds comprising of acyl, amino, halo, nitro, styryl and cyclized derivatives of bakuchiol have been evaluated against a panel of eight human cancer cell lines. Bioevaluation studies have resulted in the identification of potent cytotoxic molecules exhibiting concentration dependent growth inhibition against leukemia cancer cells with best results observed for compounds 17 and 22 exhibiting IC(50) 1.8 and 2.0 μM respectively. As evident from various biological end-points, inhibition of cell proliferation by inducing G2/M cell cycle arrest, mitochondrial membrane disruption followed by DNA fragmentation and apoptosis is demonstrated. Copyright ÂEntities:
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Year: 2011 PMID： 22245048 DOI： 10.1016/j.ejmech.2011.12.018
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514