Literature DB >> 22244751

Couple dynamics: PPARγ and its ligand partners.

Shanghai Yu1, H Eric Xu.   

Abstract

Ligand-regulated transcriptional activity is the most important property of nuclear receptors, including PPARγ. In this issue of Structure, Hughes et al. determined how the dynamic conformations of ligands and the receptor contribute to the degree of ligand-dependent activation of PPARγ, which provide further insights into design of PPARγ-based anti-diabetic drugs.
Copyright © 2012 Elsevier Ltd. All rights reserved.

Entities:  

Year:  2012        PMID： 22244751      PMCID： PMC3756547          DOI： 10.1016/j.str.2011.12.002

Source DB:  PubMed          Journal:  Structure        ISSN： 0969-2126            Impact factor:   5.006


  12 in total

1.  PPAR gamma is required for placental, cardiac, and adipose tissue development.

Authors:  Y Barak; M C Nelson; E S Ong; Y Z Jones; P Ruiz-Lozano; K R Chien; A Koder; R M Evans
Journal:  Mol Cell       Date:  1999-10       Impact factor: 17.970

2.  Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha.

Authors:  H Eric Xu; Thomas B Stanley; Valerie G Montana; Millard H Lambert; Barry G Shearer; Jeffery E Cobb; David D McKee; Cristin M Galardi; Kelli D Plunket; Robert T Nolte; Derek J Parks; John T Moore; Steven A Kliewer; Timothy M Willson; Julie B Stimmel
Journal:  Nature       Date:  2002-02-14       Impact factor: 49.962

3.  Ligand and receptor dynamics contribute to the mechanism of graded PPARγ agonism.

Authors:  Travis S Hughes; Michael J Chalmers; Scott Novick; Dana S Kuruvilla; Mi Ra Chang; Theodore M Kamenecka; Mark Rance; Bruce A Johnson; Thomas P Burris; Patrick R Griffin; Douglas J Kojetin
Journal:  Structure       Date:  2012-01-11       Impact factor: 5.006

4.  The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones.

Authors:  T M Willson; J E Cobb; D J Cowan; R W Wiethe; I D Correa; S R Prakash; K D Beck; L B Moore; S A Kliewer; J M Lehmann
Journal:  J Med Chem       Date:  1996-02-02       Impact factor: 7.446

5.  Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors.

Authors:  R T Gampe; V G Montana; M H Lambert; A B Miller; R K Bledsoe; M V Milburn; S A Kliewer; T M Willson; H E Xu
Journal:  Mol Cell       Date:  2000-03       Impact factor: 17.970

6.  Ligand-dependent and -independent regulation of PPAR gamma and orphan nuclear receptors.

Authors:  H Eric Xu; Yong Li
Journal:  Sci Signal       Date:  2008-12-02       Impact factor: 8.192

7.  Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5.

Authors:  Jang Hyun Choi; Alexander S Banks; Jennifer L Estall; Shingo Kajimura; Pontus Boström; Dina Laznik; Jorge L Ruas; Michael J Chalmers; Theodore M Kamenecka; Matthias Blüher; Patrick R Griffin; Bruce M Spiegelman
Journal:  Nature       Date:  2010-07-22       Impact factor: 49.962

8.  Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma.

Authors:  R T Nolte; G B Wisely; S Westin; J E Cobb; M H Lambert; R Kurokawa; M G Rosenfeld; T M Willson; C K Glass; M V Milburn
Journal:  Nature       Date:  1998-09-10       Impact factor: 49.962

9.  Partial agonists activate PPARgamma using a helix 12 independent mechanism.

Authors:  John B Bruning; Michael J Chalmers; Swati Prasad; Scott A Busby; Theodore M Kamenecka; Yuanjun He; Kendall W Nettles; Patrick R Griffin
Journal:  Structure       Date:  2007-10       Impact factor: 5.006

10.  Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation.

Authors:  Jang Hyun Choi; Alexander S Banks; Theodore M Kamenecka; Scott A Busby; Michael J Chalmers; Naresh Kumar; Dana S Kuruvilla; Youseung Shin; Yuanjun He; John B Bruning; David P Marciano; Michael D Cameron; Dina Laznik; Michael J Jurczak; Stephan C Schürer; Dušica Vidović; Gerald I Shulman; Bruce M Spiegelman; Patrick R Griffin
Journal:  Nature       Date:  2011-09-04       Impact factor: 49.962
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  7 in total

1.  Identification of a novel selective PPARγ ligand with a unique binding mode and improved therapeutic profile in vitro.

Authors:  Wei Yi; Jingjing Shi; Guanguan Zhao; X Edward Zhou; Kelly Suino-Powell; Karsten Melcher; H Eric Xu
Journal:  Sci Rep       Date:  2017-01-27       Impact factor: 4.379

2.  Elucidating the Novel Mechanism of Ligustrazine in Preventing Postoperative Peritoneal Adhesion Formation.

Authors:  Lili Yang; Zhengjun Li; Yao Chen; Feiyan Chen; Haopeng Sun; Min Zhao; Yanqi Chen; Yali Wang; Wenlin Li; Li Zeng; Yaoyao Bian
Journal:  Oxid Med Cell Longev       Date:  2022-03-10       Impact factor: 6.543

Review 3.  The Agonists of Peroxisome Proliferator-Activated Receptor-γ for Liver Fibrosis.

Authors:  Jingjing Li; Chuanyong Guo; Jianye Wu
Journal:  Drug Des Devel Ther       Date:  2021-06-18       Impact factor: 4.162

Review 4.  Mediterranean Diet and Neurodegenerative Diseases: The Neglected Role of Nutrition in the Modulation of the Endocannabinoid System.

Authors:  Federica Armeli; Alessio Bonucci; Elisa Maggi; Alessandro Pinto; Rita Businaro
Journal:  Biomolecules       Date:  2021-05-24

5.  Ligand Activation of PPARγ by Ligustrazine Suppresses Pericyte Functions of Hepatic Stellate Cells via SMRT-Mediated Transrepression of HIF-1α.

Authors:  Feng Zhang; Shuai Lu; Jianlin He; Huanhuan Jin; Feixia Wang; Li Wu; Jiangjuan Shao; Anping Chen; Shizhong Zheng
Journal:  Theranostics       Date:  2018-01-01       Impact factor: 11.556

6.  Chiglitazar Preferentially Regulates Gene Expression via Configuration-Restricted Binding and Phosphorylation Inhibition of PPARγ.

Authors:  De-Si Pan; Wei Wang; Nan-Song Liu; Qian-Jiao Yang; Kun Zhang; Jing-Zhong Zhu; Song Shan; Zhi-Bin Li; Zhi-Qiang Ning; Laiqiang Huang; Xian-Ping Lu
Journal:  PPAR Res       Date:  2017-09-19       Impact factor: 4.964

7.  Identification and structural insight of an effective PPARγ modulator with improved therapeutic index for anti-diabetic drug discovery.

Authors:  Haowen Jiang; X Edward Zhou; Jingjing Shi; Zhi Zhou; Guanguan Zhao; Xinwen Zhang; Yili Sun; Kelly Suino-Powell; Lei Ma; Hui Gao; Xiyong Yu; Jia Li; Jingya Li; Karsten Melcher; H Eric Xu; Wei Yi
Journal:  Chem Sci       Date:  2020-01-21       Impact factor: 9.825
  7 in total

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