Literature DB >> 22243670

Neuraminidase H275Y and hemagglutinin D222G mutations in a fatal case of 2009 pandemic influenza A (H1N1) virus infection.

Aaron DeVries1, Jason Wotton, Christine Lees, David Boxrud, Timothy Uyeki, Ruth Lynfield.   

Abstract

Oseltamivir-resistant 2009 H1N1 influenza virus infections associated with neuraminidase (NA) H275Y have been identified sporadically. Strains possessing the hemagglutinin (HA) D222G mutation have been detected in small numbers of fatal 2009 H1N1 cases. We report the first clinical description of 2009 H1N1 virus infection with both NA-H275Y and HA-D222G mutations detected by pyrosequencing of bronchioalveolar lavage fluid obtained on symptom day 19. The 59-year-old immunosuppressed patient had multiple conditions conferring higher risk of prolonged viral replication and severe illness and died on symptom day 34. Further investigations are needed to determine the significance of infection with strains possessing NA-H275Y and HA-D222G.
© 2012 Blackwell Publishing Ltd.

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Year:  2012        PMID： 22243670      PMCID： PMC4941703          DOI： 10.1111/j.1750-2659.2011.00329.x

Source DB:  PubMed          Journal:  Influenza Other Respir Viruses        ISSN： 1750-2640            Impact factor:   4.380


  15 in total

1.  Occurrence of haemagglutinin mutation D222G in pandemic influenza A(H1N1) infected patients in the West of Scotland, United Kingdom, 2009-10.

Authors:  R R Miller; A R MacLean; R N Gunson; W F Carman
Journal:  Euro Surveill       Date:  2010-04-22

2.  Preliminary review of D222G amino acid substitution in the haemagglutinin of pandemic influenza A (H1N1) 2009 viruses.

Authors: 
Journal:  Wkly Epidemiol Rec       Date:  2010-01-22

3.  Glycan microarray analysis of the hemagglutinins from modern and pandemic influenza viruses reveals different receptor specificities.

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Journal:  J Mol Biol       Date:  2005-11-18       Impact factor: 5.469

4.  Clinical and virological course of infection with haemagglutinin D222G mutant strain of 2009 pandemic influenza A (H1N1) virus.

Authors:  Paul K S Chan; Nelson Lee; Gavin M Joynt; K W Choi; Jo L K Cheung; Apple C M Yeung; Philip Lam; Rity Wong; Bo-Wah Leung; Hing-Yu So; Wai-Yip Lam; David C S Hui
Journal:  J Clin Virol       Date:  2011-02-16       Impact factor: 3.168

5.  Detection of hemagglutinin variants of the pandemic influenza A (H1N1) 2009 virus by pyrosequencing.

Authors:  Marnie Levine; Tiffany G Sheu; Larisa V Gubareva; Vasiliy P Mishin
Journal:  J Clin Microbiol       Date:  2011-02-09       Impact factor: 5.948

6.  Detection of molecular markers of drug resistance in 2009 pandemic influenza A (H1N1) viruses by pyrosequencing.

Authors:  Varough M Deyde; Tiffany G Sheu; A Angelica Trujillo; Margaret Okomo-Adhiambo; Rebecca Garten; Alexander I Klimov; Larisa V Gubareva
Journal:  Antimicrob Agents Chemother       Date:  2009-12-22       Impact factor: 5.191

7.  Virulence-associated substitution D222G in the hemagglutinin of 2009 pandemic influenza A(H1N1) virus affects receptor binding.

Authors:  Salin Chutinimitkul; Sander Herfst; John Steel; Anice C Lowen; Jianqiang Ye; Debby van Riel; Eefje J A Schrauwen; Theo M Bestebroer; Björn Koel; David F Burke; Kyle H Sutherland-Cash; Chris S Whittleston; Colin A Russell; David J Wales; Derek J Smith; Marcel Jonges; Adam Meijer; Marion Koopmans; Guus F Rimmelzwaan; Thijs Kuiken; Albert D M E Osterhaus; Adolfo García-Sastre; Daniel R Perez; Ron A M Fouchier
Journal:  J Virol       Date:  2010-09-15       Impact factor: 5.103

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Journal:  Virology       Date:  1999-09-15       Impact factor: 3.616

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Authors:  Anthony E Fiore; Alicia Fry; David Shay; Larisa Gubareva; Joseph S Bresee; Timothy M Uyeki
Journal:  MMWR Recomm Rep       Date:  2011-01-21

10.  Oseltamivir resistance in adult oncology and hematology patients infected with pandemic (H1N1) 2009 virus, Australia.

Authors:  Adrian R Tramontana; Biju George; Aeron C Hurt; Joseph S Doyle; Katherine Langan; Alistair B Reid; Janet M Harper; Karin Thursky; Leon J Worth; Dominic E Dwyer; C Orla Morrissey; Paul D R Johnson; Kirsty L Buising; Simon James Harrison; John F Seymour; Patricia E Ferguson; Bin Wang; Justin T Denholm; Allen C Cheng; Monica Slavin
Journal:  Emerg Infect Dis       Date:  2010-07       Impact factor: 6.883
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  6 in total

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Journal:  J Virol       Date:  2014-01-08       Impact factor: 5.103

2.  Emergence of a Novel Reassortant H5N3 Avian Influenza Virus in Korean Mallard Ducks in 2018.

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3.  Increased virulence of neuraminidase inhibitor-resistant pandemic H1N1 virus in mice: potential emergence of drug-resistant and virulent variants.

Authors:  Min-Suk Song; Yun Hee Baek; Eun-Ha Kim; Su-Jin Park; Semi Kim; Gyo-Jin Lim; Hyeok-Il Kwon; Philippe Noriel Q Pascua; Arun G Decano; Byeong-Jae Lee; Young-Il Kim; Richard J Webby; Young-Ki Choi
Journal:  Virulence       Date:  2013-08-02       Impact factor: 5.882

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5.  Next-Generation Sequencing Analysis of the Within-Host Genetic Diversity of Influenza A(H1N1)pdm09 Viruses in the Upper and Lower Respiratory Tracts of Patients with Severe Influenza.

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6.  A novel pyrosequencing assay for the detection of neuraminidase inhibitor resistance-conferring mutations among clinical isolates of avian H7N9 influenza virus.

Authors:  Yuhua Qi; Huan Fan; Xian Qi; Zheng Zhu; Xiling Guo; Yin Chen; Yiyue Ge; Kangchen Zhao; Tao Wu; Yan Li; Yunfeng Shan; Minghao Zhou; Zhiyang Shi; Hua Wang; Lunbiao Cui
Journal:  Virus Res       Date:  2013-11-05       Impact factor: 3.303
  6 in total

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