Literature DB >> 22243554

Fibromyalgia in patients with rheumatoid arthritis: driven by depression or joint damage?

S R Kapoor1, S L Hider, A Brownfield, D L Mattey, J C Packham.   

Abstract

OBJECTIVES: Studies have shown an increased incidence of fibromyalgia (FMS) in RA patients. The aims of this study were to explore the effect of mood and disease damage on the prevalence of FMS.
METHODS: RA patients underwent a standardised clinical assessment, including disease activity (DAS-28), disease damage (mechanical joint score, MJS), fibromyalgia tender point assessment and the Hospital Anxiety and Depression Scale (HADS) and Health Assessment Questionnaire (HAQ). Patients were classified with FMS using two criteria a) tender-swollen joint count was ≥7 or b) tender point score of ≥11/18.
RESULTS: 44/285 (15%) patients were classified as having FMS using the joint count difference of ≥7, compared to 18/285 (6%) using the tender point score of >11. Using the joint count difference to classify patients as having FMS, those with FMS had higher HAQ scores than those without FMS (2.12 vs. 1.5, p<0.0001). Although the DAS-28 was higher in this group (5.4 vs. 3.82, p<0.0001), the MJS was similar (8 vs. 7, p=0.19), suggesting similar levels of joint damage. Those classified as having FMS were more likely to have HAD-D scores of >11 (25% vs. 6%, p=0.0001).
CONCLUSIONS: Coexistent FMS was common in our cohort, although using the tender point count to define FMS classified fewer patients with FMS. Within this group those with FMS had higher levels of depression but similar scores for joint damage indicating that in this cohort FMS and poorer physical functioning is mediated by low mood rather than joint damage.

Entities:  

Mesh:

Year:  2012        PMID: 22243554

Source DB:  PubMed          Journal:  Clin Exp Rheumatol        ISSN: 0392-856X            Impact factor:   4.473


  3 in total

1.  Swollen to tender joint count ratio: a novel combination of routine measures to assess pain and treatment response in rheumatoid arthritis.

Authors:  Yvonne C Lee
Journal:  Arthritis Care Res (Hoboken)       Date:  2014-02       Impact factor: 4.794

Review 2.  Concomitant fibromyalgia complicating chronic inflammatory arthritis: a systematic review and meta-analysis.

Authors:  Stephen J Duffield; Natasha Miller; Sizheng Zhao; Nicola J Goodson
Journal:  Rheumatology (Oxford)       Date:  2018-08-01       Impact factor: 7.580

3.  Comorbidity of Fibromyalgia in Primary Knee Osteoarthritis: Potential Impact on Functional Status and Quality of Life.

Authors:  Marwa Yahia Mahgoub; Basant Mohamed Elnady; Haytham Sayed Abdelkader; Raghdaa Abdelkhaleq Abdelhalem; Waleed Ahmed Hassan
Journal:  Open Access Rheumatol       Date:  2020-05-05
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.