| Literature DB >> 22241118 |
Magda Cristina Bernardino Castilho1, Angélica Nascimento Martins, Ingrid Siciliano Horbach, Renata de Mello Perez, Fatima Aparecida Ferreira Figueiredo, Paulo de Tarso Aparecida Pinto, Leticia Cancela Nabuco, Dirce Bonfim de Lima, Amílcar Tanuri, Luis Cristóvão Porto, Orlando da Costa Ferreira Júnior.
Abstract
Mutations located in the 109-amino acid fragment of NS5B are typically associated with resistance to interferon (IFN) and ribavirin (RIB) and to new antiviral drugs. The prevalence of these mutations was examined in 69 drug-naïve individuals with hepatitis C virus (HCV) infections in Rio de Janeiro, Brazil. Mutations related to non-response to IFN/RIB were observed in all subtypes studied (1a, 1b, 2b, 3a and 4). The most common mutation was Q309R, present in all subtypes, except subtype 2b with frequency above 20%. D244N was detected only in subtype 3a and A333E was detected only in subtype 2b. We did not detect the S282T, S326G or T329I mutations in any of the samples analysed. Of note, the C316N mutation, previously related to a new non-nucleoside compound (HCV796 and AG-021541), was observed in only eight of 33 (24%) samples from subtype 1b. Site 316 was under positive selection in this HCV variant. Our data highlight the presence of previously described resistance mutations in HCV genotypes from drug-naïve patients.Entities:
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Year: 2011 PMID： 22241118 DOI： 10.1590/s0074-02762011000800011
Source DB: PubMed Journal: Mem Inst Oswaldo Cruz ISSN： 0074-0276 Impact factor: 2.743