Literature DB >> 222411

Diazepam potentiation of purinergic depression of central neurons.

J W Phillis.   

Abstract

Intravenously or iontophoretically applied diazepam potentiated the depressant action of iontophoretically applied 5'-AMP on the spontaneous firing of rat cerebral cortical neurons. This potentiation of purinergic depression may be a result of the previously reported inhibition by diazepam of uptake of adenosine into brain tissues.

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Year:  1979        PMID： 222411     DOI： 10.1139/y79-066

Source DB:  PubMed          Journal:  Can J Physiol Pharmacol        ISSN： 0008-4212            Impact factor:   2.273


  7 in total

Review 1.  Methylxanthines, seizures, and excitotoxicity.

Authors:  Detlev Boison
Journal:  Handb Exp Pharmacol       Date:  2011

2.  Benzodiazepines alter nucleotide and nucleoside hydrolysis in zebrafish (Danio rerio) brain.

Authors:  Stefani Altenhofen; Fernanda Francine Zimmermann; Lauryn Silva Barreto; Josiane Woutheres Bortolotto; Luiza Wilges Kist; Mauricio Reis Bogo; Carla Denise Bonan
Journal:  J Neural Transm (Vienna)       Date:  2015-03-15       Impact factor: 3.575

3.  Potentiation of the effects of adenosine on isolated cardiac and smooth muscle by diazepam.

Authors:  A S Clanachan; R J Marshall
Journal:  Br J Pharmacol       Date:  1980       Impact factor: 8.739

4.  Alprazolam, caffeine and their interaction: relating DRL performance to pharmacokinetics.

Authors:  C E Lau; J Wang
Journal:  Psychopharmacology (Berl)       Date:  1996-07       Impact factor: 4.530

5.  Involvement of adenosine receptor activities in aggressive responses produced by clonidine in mice.

Authors:  I Ushijima; T Katsuragi; T Furukawa
Journal:  Psychopharmacology (Berl)       Date:  1984       Impact factor: 4.530

6.  Effects of diazepam on adenosine and acetylcholine release from rat cerebral cortex: further evidence for a purinergic mechanism in action of diazepam.

Authors:  R K Phillis JW Siemens; R K Siemens; P H Wu
Journal:  Br J Pharmacol       Date:  1980-10       Impact factor: 8.739

7.  The site of action of muscle relaxant purine nucleosides.

Authors:  P J Buckle; I Spence
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1981-02       Impact factor: 3.000
  7 in total

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