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Literature DB >> 22237969

The roles of neutral sphingomyelinases in neurological pathologies.

Abstract

The neutral sphingomyelinases (N-SMases) are a group of Mg²⁺-dependent enzymes with a pH optimum in the neutral range. N-SMases catalyze the conversion of sphingomyelin to ceramide and have been found particularly enriched in brain tissue. N-SMase activity has been implicated in many physiological and pathological processes affecting the brain and nervous system. In this review, we discuss the proposed functions of N-SMase with a particular emphasis on its role in neurological disorders, such as age-related neurodegeneration, Alzheimer's disease, HIV-associated dementia, atherosclerosis, ischemia-reperfusion injury, and cancer.

Entities: Chemical Disease Gene

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Year: 2012 PMID： 22237969 DOI： 10.1007/s11064-011-0692-y

Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996

139 in total

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2. Glutathione deficiency intensifies ischaemia-reperfusion induced cardiac dysfunction and oxidative stress.

Authors: S Leichtweis; L L Ji
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Journal: Basic Res Cardiol Date: 2001 May-Jun Impact factor: 17.165

5. Nerve growth factor, sphingomyelins, and sensitization in sensory neurons.

Authors: Grant D Nicol
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Journal: PLoS One Date: 2010-03-23 Impact factor: 3.240

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Authors: Yinglin Wang; Shaojun Zhu; Timothy F Cloughesy; Linda M Liau; Paul S Mischel
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8. Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism.

Authors: Norma Marchesini; Chiara Luberto; Yusuf A Hannun
Journal: J Biol Chem Date: 2003-02-03 Impact factor: 5.157

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Authors: H Fillit; W H Ding; L Buee; J Kalman; L Altstiel; B Lawlor; G Wolf-Klein
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20 in total

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2. Theoretical investigations into the intermolecular hydrogen-bonding interactions of N-(hydroxymethyl)acetamide dimers.

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Journal: J Mol Model Date: 2018-05-31 Impact factor: 1.810

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5. Sphingomyelin encrypts tissue factor: ATP-induced activation of A-SMase leads to tissue factor decryption and microvesicle shedding.

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Review 6. Lysosomal membrane permeabilization as a key player in brain ischemic cell death: a "lysosomocentric" hypothesis for ischemic brain damage.

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7. A comparison of trabecular meshwork sphingolipids and ceramides of ocular normotensive and hypertensive states of DBA/2J mice.

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Journal: J Ocul Pharmacol Ther Date: 2013-12-09 Impact factor: 2.671