Literature DB >> 22236648

Polymorphisms in the folate-metabolizing genes MTR, MTRR, and CBS and breast cancer risk.

Alexandra S Weiner1, Uljana A Boyarskikh, Elena N Voronina, Inna A Selezneva, Tatiana V Sinkina, Alexandr F Lazarev, Valentina D Petrova, Maxim L Filipenko.   

Abstract

Alterations in the nucleotide sequences of folate-metabolizing genes can increase the risk of malignant transformation. The aim of our study was to investigate the association of three single-nucleotide polymorphisms (SNPs) in the folate-metabolizing genes - A2756G MTR, A66G MTRR, and 844ins68 CBS - which have putative functional significance in breast cancer risk. The allele and genotype frequencies of the SNPs were determined in a case group (840 women with sporadic breast cancer) and a control group (770 women). No statistically significant association of studied SNPs with breast cancer was revealed. A meta-analysis, which included data obtained from the literature and the present research, did not reveal any statistically significant associations of these SNPs with breast cancer. The results obtained provide evidence that these SNPs are not involved in the development of breast cancer. Copyright Â
© 2011 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID： 22236648     DOI： 10.1016/j.canep.2011.11.010

Source DB:  PubMed          Journal:  Cancer Epidemiol        ISSN： 1877-7821            Impact factor:   2.984


  14 in total

1.  Single-nucleotide polymorphisms in one-carbon metabolism genes, Mediterranean diet and breast cancer risk: a case-control study in the Greek-Cypriot female population.

Authors:  Maria G Kakkoura; Christiana A Demetriou; Maria A Loizidou; Giorgos Loucaides; Ioanna Neophytou; Yiola Marcou; Andreas Hadjisavvas; Kyriacos Kyriacou
Journal:  Genes Nutr       Date:  2015-01-21       Impact factor: 5.523

2.  Relationships among folate, alcohol consumption, gene variants in one-carbon metabolism and p16INK4a methylation and expression in healthy breast tissues.

Authors:  Adana A Llanos; Ramona G Dumitrescu; Theodore M Brasky; Zhenhua Liu; Joel B Mason; Catalin Marian; Kepher H Makambi; Scott L Spear; Bhaskar V S Kallakury; Jo L Freudenheim; Peter G Shields
Journal:  Carcinogenesis       Date:  2014-10-24       Impact factor: 4.944

3.  Genetic variants in one-carbon metabolism genes and breast cancer risk in European American and African American women.

Authors:  Zhihong Gong; Song Yao; Gary Zirpoli; Ting-Yuan David Cheng; Michelle Roberts; Thaer Khoury; Gregory Ciupak; Warren Davis; Karen Pawlish; Lina Jandorf; Dana H Bovbjerg; Elisa V Bandera; Christine B Ambrosone
Journal:  Int J Cancer       Date:  2015-01-29       Impact factor: 7.396

4.  Genetic variations in the one-carbon metabolism pathway genes and susceptibility to hepatocellular carcinoma risk: a case-control study.

Authors:  Heng Zhang; Chunhe Liu; Yu-Chen Han; Zuohong Ma; Haiyan Zhang; Yinan Ma; Xiaofang Liu
Journal:  Tumour Biol       Date:  2014-10-16

5.  Population-level diversity in the association of genetic polymorphisms of one-carbon metabolism with breast cancer risk.

Authors:  Shaik Mohammad Naushad; Chandrasekhar Divya; M Janaki Ramaiah; Tajamul Hussain; Salman A Alrokayan; Vijay Kumar Kutala
Journal:  J Community Genet       Date:  2016-08-19

6.  The association between the 844ins68 polymorphism in the CBS gene and breast cancer.

Authors:  Martha Patricia Gallegos-Arreola; Luis Eduardo Figuera-Villanueva; Adriana Ramos-Silva; Efraín Salas-González; Ana María Puebla-Pérez; Valeria Peralta-Leal; José Elías García-Ortiz; Ingrid Patricia Dávalos-Rodríguez; Guillermo Moisés Zúñiga-González
Journal:  Arch Med Sci       Date:  2014-12-22       Impact factor: 3.318

7.  The transcription factor FOXL2 mobilizes estrogen signaling to maintain the identity of ovarian granulosa cells.

Authors:  Adrien Georges; David L'Hôte; Anne Laure Todeschini; Aurélie Auguste; Bérangère Legois; Alain Zider; Reiner A Veitia
Journal:  Elife       Date:  2014-11-04       Impact factor: 8.140

8.  Functional variants of the 5-methyltetrahydrofolate-homocysteine methyltransferase gene significantly increase susceptibility to prostate cancer: Results from an ethnic Han Chinese population.

Authors:  Yuan-Yuan Qu; Shu-Xian Zhou; Xuan Zhang; Rui Zhao; Cheng-Yuan Gu; Kun Chang; Xiao-Qun Yang; Hua-Lei Gan; Bo Dai; Hai-Liang Zhang; Guo-Hai Shi; Yao Zhu; Ding-Wei Ye; Jian-Yuan Zhao
Journal:  Sci Rep       Date:  2016-11-03       Impact factor: 4.379

9.  Geographical distribution of MTHFR C677T, A1298C and MTRR A66G gene polymorphisms in China: findings from 15357 adults of Han nationality.

Authors:  Boyi Yang; Yuyan Liu; Yongfang Li; Shujun Fan; Xueyuan Zhi; Xiangxiang Lu; Da Wang; Quanmei Zheng; Yinuo Wang; Yanxun Wang; Guifan Sun
Journal:  PLoS One       Date:  2013-03-05       Impact factor: 3.240

Review 10.  Implications of DNA Methylation in Parkinson's Disease.

Authors:  Ernesto Miranda-Morales; Karin Meier; Ada Sandoval-Carrillo; José Salas-Pacheco; Paola Vázquez-Cárdenas; Oscar Arias-Carrión
Journal:  Front Mol Neurosci       Date:  2017-07-18       Impact factor: 5.639
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