Literature DB >> 22235396

In vitro study of neuroprotective properties of GK-2, a new original nerve growth factor mimetic.

T A Antipova1, T A Gudasheva, S B Seredenin.   

Abstract

New nerve growth factor (NGF) mimetic GK-2, a substituted dimeric dipeptide, in a concentration of up to 10(-9)M produced a protective effect on the culture of immortalized mouse hippocampal neurons (line HT-22) after addition of H(2)O(2)and glutamate. GK-2 in a concentration of 10(-8)M protected rat PC-12 pheochromocytoma cells from the neurotoxin MPTP. The neuroprotective effect of this peptide on the model of oxidative stress was also observed in the primary culture of embryonic rat hippocampal neurons.

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Year:  2011        PMID： 22235396     DOI： 10.1007/s10517-011-1202-6

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  8 in total

1.  Neurotrophic Effects of Mu Bie Zi (Momordica cochinchinensis) Seed Elucidated by High-Throughput Screening of Natural Products for NGF Mimetic Effects in PC-12 Cells.

Authors:  E Mazzio; B Georges; O McTier; Karam F A Soliman
Journal:  Neurochem Res       Date:  2015-04-11       Impact factor: 3.996

2.  Low-Molecular-Weight Perorally Active Nerve Growth Factor Mimetic Reduces Manifestations of Diabetic Neuropathy in Wistar Rats.

Authors:  S V Ivanov; R U Ostrovskaya; A S Khlybova; T A Gudasheva
Journal:  Bull Exp Biol Med       Date:  2022-05-27       Impact factor: 0.804

3.  In Silico Investigation of the Binding of MCoTI-II Plant Defense Knottin to the γ-NGF Serine Protease of the 7S Nerve Growth Factor Complex and Biological Activity of Its NGF Mimetic Properties.

Authors:  Peter M Jones; Elizabeth Mazzio; Karam Soliman; Anthony M George
Journal:  J Phys Chem B       Date:  2019-10-21       Impact factor: 2.991

Review 4.  Peptides Derived from Growth Factors to Treat Alzheimer's Disease.

Authors:  Suzanne Gascon; Jessica Jann; Chloé Langlois-Blais; Mélanie Plourde; Christine Lavoie; Nathalie Faucheux
Journal:  Int J Mol Sci       Date:  2021-06-04       Impact factor: 5.923

5.  Bioactivity-Guided Isolation of Neuritogenic Factor from the Seeds of the Gac Plant (Momordica cochinchinensis).

Authors:  E Mazzio; R Badisa; S Eyunni; S Ablordeppey; B George; K F A Soliman
Journal:  Evid Based Complement Alternat Med       Date:  2018-05-31       Impact factor: 2.629

6.  A Nerve Growth Factor Dipeptide Mimetic Stimulates Neurogenesis and Synaptogenesis in the Hippocampus and Striatum of Adult Rats with Focal Cerebral Ischemia.

Authors:  T A Gudasheva; P Yu Povarnina; A A Volkova; S V Kruglov; T A Antipova; S B Seredenin
Journal:  Acta Naturae       Date:  2019 Jul-Sep       Impact factor: 1.845

7.  Dimeric dipeptide mimetics of the nerve growth factor Loop 4 and Loop 1 activate TRKA with different patterns of intracellular signal transduction.

Authors:  Tatyana A Gudasheva; Polina Yu Povarnina; Tatyana A Antipova; Yulia N Firsova; Mark A Konstantinopolsky; Sergey B Seredenin
Journal:  J Biomed Sci       Date:  2015-12-08       Impact factor: 8.410

Review 8.  Novel Technologies for Dipeptide Drugs Design and their Implantation.

Authors:  Tatiana A Gudasheva; Rita U Ostrovskaya; Sergey B Seredenin
Journal:  Curr Pharm Des       Date:  2018       Impact factor: 3.116
  8 in total

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