Literature DB >> 22234721

Drug overdose resulting in quadriplegia.

Teresa S Wang1, Betsy H Grunch, Jessica R Moreno, Carlos A Bagley, Oren N Gottfried.   

Abstract

PURPOSE: To describe a case of cervical flexion myelopathy resulting from a drug overdose.
METHODS: A 56-year-old male presented to the emergency department unable to move his extremities following drug overdose. Neurological examination revealed him to be at C6 ASIA A spinal cord injury. The CT of his cervical spine revealed no fracture; however, an MRI revealed cord edema extending from C3 to C6 as well as posterior paraspinal signal abnormalities suggestive of ligamentous injury.
RESULTS: The patient underwent a posterior cervical laminectomy and fusion from C3 to C7. Neurologically he regained 3/5 bilateral tricep function and 2/5 grip; otherwise, he remained at ASIA A spinal cord injury at 6 months.
CONCLUSION: Our patient suffered a spinal cord injury likely due to existing cervical stenosis, and in addition to an overdose of sedating medications, he likely sat in flexed neck position for prolonged period of time with the inability to modify his position. This likely resulted in cervical spine vascular and/or neurological compromise producing an irreversible spinal cord injury. Spinal cord injury is a rare finding in patients presenting with drug overdose. The lack of physical exam findings suggestive of trauma may delay prompt diagnosis and treatment, and thus clinicians must have a high index of suspicion when evaluating patients in this setting.

Entities:  

Mesh:

Year:  2012        PMID: 22234721      PMCID: PMC3369047          DOI: 10.1007/s00586-011-2143-5

Source DB:  PubMed          Journal:  Eur Spine J        ISSN: 0940-6719            Impact factor:   3.134


  10 in total

1.  Midcervical flexion myelopathy after posterior fossa surgery in the sitting position: case report.

Authors:  T Haisa; T Kondo
Journal:  Neurosurgery       Date:  1996-04       Impact factor: 4.654

2.  Anterior spinal decompression and fusion for cervical flexion myelopathy in young patients.

Authors:  Kei Watanabe; Kazuhiro Hasegawa; Toru Hirano; Naoto Endo; Akiyoshi Yamazaki; Takao Homma
Journal:  J Neurosurg Spine       Date:  2005-08

3.  [A mechanism of juvenile muscular atrophy localized in the hand and forearm (Hirayama's disease)--flexion myelopathy with tight dural canal in flexion].

Authors:  S Kikuchi; K Tashiro; M Kitagawa; Y Iwasaki; H Abe
Journal:  Rinsho Shinkeigaku       Date:  1987-04

4.  Cervical flexion myelopathy after valproic acid overdose.

Authors:  K L Kaye; D Ramsay; G B Young
Journal:  Spine (Phila Pa 1976)       Date:  2001-10-01       Impact factor: 3.468

5.  Quadriplegia in a patient who underwent posterior fossa surgery in the prone position. Case report.

Authors:  Cheng-Shyuan Rau; Cheng-Loong Liang; Chun-Chung Lui; Tao-Chen Lee; Kang Lu
Journal:  J Neurosurg       Date:  2002-01       Impact factor: 5.115

Review 6.  Spinal cord injury. The role of vascular damage in the pathogenesis of central hemorrhagic necrosis.

Authors:  E Nelson; S D Gertz; M L Rennels; T B Ducker; O R Blaumanis
Journal:  Arch Neurol       Date:  1977-06

7.  Pathophysiology and treatment for cervical flexion myelopathy.

Authors:  Yoshinori Fujimoto; Shinichi Oka; Nobuhiro Tanaka; Kohichiro Nishikawa; Hiroyuki Kawagoe; Itsushi Baba
Journal:  Eur Spine J       Date:  2002-02-07       Impact factor: 3.134

8.  Window of opportunity: flexion myelopathy after drug overdose.

Authors:  Allen S Nielsen; Denise M Damek
Journal:  J Emerg Med       Date:  2008-12-11       Impact factor: 1.484

9.  Thoracic flexion myelopathy. Case report.

Authors:  K Mii; S Shimizu; C Tanaka; K Matsumori; K Hasegawa; Y Mizoi
Journal:  J Neurosurg       Date:  1995-06       Impact factor: 5.115

10.  Cervical flexion myelopathy: a "tight dural canal mechanism". Case report.

Authors:  Y Iwasaki; K Tashiro; S Kikuchi; M Kitagawa; T Isu; H Abe
Journal:  J Neurosurg       Date:  1987-06       Impact factor: 5.115

  10 in total
  1 in total

1.  Cervical Myelopathy Associated with Deep Neck Muscle Rhabdomyolysis after Polysubstance Abuse: A Case Report.

Authors:  Jari Honkaniemi; Jaana Rummukainen; Pinne Väänänen; Matti Vuorialho
Journal:  Case Rep Neurol       Date:  2022-02-07
  1 in total

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