| Literature DB >> 22234308 |
Tapan K Bera1, Dawn A Walker, Richard J Sherins, Ira Pastan.
Abstract
The POTE gene family encodes very closely related proteins that are highly expressed in testis and in many cancers. Recent studies indicate that the POTE proteins have a pro-apoptotic function. To examine if POTE is associated with cells that are undergoing apoptosis in testis, we determined the cellular location of POTE and of Cleaved Caspase-3 in testicular tissues from 26 azoospermic men. We found intense expression of POTE in round spermatids that are undergoing apoptosis, which are positive for Cleaved Caspase-3. This study suggests POTE may have a role in apoptosis in the human testis. Published by Elsevier Inc.Entities:
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Year: 2012 PMID： 22234308 PMCID： PMC3278037 DOI： 10.1016/j.bbrc.2011.12.125
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575