| Literature DB >> 22234249 |
Abstract
Population stratification occurs when a study population is comprised of several sub-populations, and can result in increased false positive findings in genomewide-association studies. Recently published work shows that sub-population-specific positive assortative mating at the genotypic level results in population stratification. We show that if the allele frequency of a single nucleotide polymorphism responsible for a trait varies between sub-populations and there is no dominance variance, then the heritability of the trait increases, primarily due to an increase in the additive genetic variance of the trait.Mesh:
Year: 2012 PMID: 22234249 PMCID: PMC3330693 DOI: 10.1038/hdy.2011.124
Source DB: PubMed Journal: Heredity (Edinb) ISSN: 0018-067X Impact factor: 3.821