Literature DB >> 22234249

A brief note on the resemblance between relatives in the presence of population stratification.

R Sebro1, N J Risch.   

Abstract

Population stratification occurs when a study population is comprised of several sub-populations, and can result in increased false positive findings in genomewide-association studies. Recently published work shows that sub-population-specific positive assortative mating at the genotypic level results in population stratification. We show that if the allele frequency of a single nucleotide polymorphism responsible for a trait varies between sub-populations and there is no dominance variance, then the heritability of the trait increases, primarily due to an increase in the additive genetic variance of the trait.

Mesh:

Year:  2012        PMID: 22234249      PMCID: PMC3330693          DOI: 10.1038/hdy.2011.124

Source DB:  PubMed          Journal:  Heredity (Edinb)        ISSN: 0018-067X            Impact factor:   3.821


  9 in total

1.  Inference of population structure using multilocus genotype data.

Authors:  J K Pritchard; M Stephens; P Donnelly
Journal:  Genetics       Date:  2000-06       Impact factor: 4.562

2.  The power of the Transmission Disequilibrium Test in the presence of population stratification.

Authors:  Ronnie Sebro; John J Rogus
Journal:  Eur J Hum Genet       Date:  2010-05-05       Impact factor: 4.246

3.  Principal components analysis corrects for stratification in genome-wide association studies.

Authors:  Alkes L Price; Nick J Patterson; Robert M Plenge; Michael E Weinblatt; Nancy A Shadick; David Reich
Journal:  Nat Genet       Date:  2006-07-23       Impact factor: 38.330

4.  Testing for non-random mating: evidence for ancestry-related assortative mating in the Framingham heart study.

Authors:  Ronnie Sebro; Thomas J Hoffman; Christoph Lange; John J Rogus; Neil J Risch
Journal:  Genet Epidemiol       Date:  2010-11       Impact factor: 2.135

5.  'The missing genes: what happened to the heritability of psychiatric disorders?'.

Authors:  T J Crow
Journal:  Mol Psychiatry       Date:  2011-04       Impact factor: 15.992

Review 6.  Searching for genetic determinants in the new millennium.

Authors:  N J Risch
Journal:  Nature       Date:  2000-06-15       Impact factor: 49.962

7.  Genome-wide association approaches for identifying loci for human height genes.

Authors:  Markus Perola
Journal:  Best Pract Res Clin Endocrinol Metab       Date:  2011-02       Impact factor: 4.690

8.  Ancestry-related assortative mating in Latino populations.

Authors:  Neil Risch; Shweta Choudhry; Marc Via; Analabha Basu; Ronnie Sebro; Celeste Eng; Kenneth Beckman; Shannon Thyne; Rocio Chapela; Jose R Rodriguez-Santana; William Rodriguez-Cintron; Pedro C Avila; Elad Ziv; Esteban Gonzalez Burchard
Journal:  Genome Biol       Date:  2009-11-20       Impact factor: 13.583

Review 9.  Data and theory point to mainly additive genetic variance for complex traits.

Authors:  William G Hill; Michael E Goddard; Peter M Visscher
Journal:  PLoS Genet       Date:  2008-02-29       Impact factor: 5.917

  9 in total
  7 in total

1.  Genomic evidence for MHC disassortative mating in humans.

Authors:  Claire Dandine-Roulland; Romain Laurent; Irene Dall'Ara; Bruno Toupance; Raphaëlle Chaix
Journal:  Proc Biol Sci       Date:  2019-03-27       Impact factor: 5.349

Review 2.  Why do we pick similar mates, or do we?

Authors:  Thomas M M Versluys; Ewan O Flintham; Alex Mas-Sandoval; Vincent Savolainen
Journal:  Biol Lett       Date:  2021-11-24       Impact factor: 3.703

3.  Structured mating: Patterns and implications.

Authors:  Ronnie Sebro; Gina M Peloso; Josée Dupuis; Neil J Risch
Journal:  PLoS Genet       Date:  2017-04-06       Impact factor: 5.917

4.  Height associated variants demonstrate assortative mating in human populations.

Authors:  Xiaoyin Li; Susan Redline; Xiang Zhang; Scott Williams; Xiaofeng Zhu
Journal:  Sci Rep       Date:  2017-11-16       Impact factor: 4.379

5.  Close inbreeding and low genetic diversity in Inner Asian human populations despite geographical exogamy.

Authors:  Nina Marchi; Philippe Mennecier; Myriam Georges; Sophie Lafosse; Tatyana Hegay; Choduraa Dorzhu; Boris Chichlo; Laure Ségurel; Evelyne Heyer
Journal:  Sci Rep       Date:  2018-06-20       Impact factor: 4.379

6.  Population phenomena inflate genetic associations of complex social traits.

Authors:  Tim T Morris; Neil M Davies; Gibran Hemani; George Davey Smith
Journal:  Sci Adv       Date:  2020-04-15       Impact factor: 14.136

7.  Within-population genetic structure in beech (Fagus sylvatica L.) stands characterized by different disturbance histories: does forest management simplify population substructure?

Authors:  Andrea Piotti; Stefano Leonardi; Myriam Heuertz; Joukje Buiteveld; Thomas Geburek; Sophie Gerber; Koen Kramer; Cristina Vettori; Giovanni Giuseppe Vendramin
Journal:  PLoS One       Date:  2013-09-05       Impact factor: 3.240

  7 in total

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