Literature DB >> 2223412

A graphical presentation of the results of crossover trials.

T A Sheldon1.   

Abstract

1. Crossover designs are widely used in clinical trials. A graphical method of describing the data as well as visually indicating the extent of treatment * period interaction and overall treatment effect is presented. This plots the treatment differences between the periods for each individual against the mean of their treatment outcomes. It is recommended that this plot accompany the analysis of crossover trials in order to aid summary and interpretation especially for the non-statistician.

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Year:  1990        PMID: 2223412      PMCID: PMC1368134          DOI: 10.1111/j.1365-2125.1990.tb03782.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN: 0306-5251            Impact factor:   4.335


  3 in total

1.  THE TWO-PERIOD CHANGE-OVER DESIGN AN ITS USE IN CLINICAL TRIALS.

Authors:  J E GRIZZLE
Journal:  Biometrics       Date:  1965-06       Impact factor: 2.571

2.  The two-period cross-over clinical trial.

Authors:  M Hills; P Armitage
Journal:  Br J Clin Pharmacol       Date:  1979-07       Impact factor: 4.335

3.  A two-period crossover design for the comparison of two active treatments and placebo.

Authors:  G G Koch; I A Amara; B W Brown; T Colton; D B Gillings
Journal:  Stat Med       Date:  1989-04       Impact factor: 2.373

  3 in total
  2 in total

1.  Problems with the two stage analysis of crossover trials.

Authors:  S J Senn
Journal:  Br J Clin Pharmacol       Date:  1991-07       Impact factor: 4.335

2.  Should we cross off the crossover?

Authors:  P Armitage
Journal:  Br J Clin Pharmacol       Date:  1991-07       Impact factor: 4.335

  2 in total

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