BACKGROUND AND PURPOSE: Growth factors are thought to modulate neurological function in stroke recovery through effects in angiogenesis, neurogenesis, and neuroprotection. METHODS: We tested the association of variants in the brain-derived neurotrophic factor (BDNF), fibroblast growth factor 2 (FGF2) and vascular endothelial growth factor A (VEGFA) genes, and epistatic interactions between them, with functional outcome in a sample of 546 stroke patients. RESULTS: While none of the tested genes was independently associated with stroke outcome, two significant gene-gene interaction models were identified. One model combined one BDNF and three FGF2 markers, with a global odds ratio (OR) (95% confidence interval [CI]) of 4.15 [2.86-6.04]. The second model included one FGF2 and two VEGFA markers with a global OR [95% CI] = 2.54 [1.76-3.67]. CONCLUSIONS: The results provide evidence for gene interactions in stroke outcome, highlighting the complexity of the recovery mechanisms after a stroke event.
BACKGROUND AND PURPOSE: Growth factors are thought to modulate neurological function in stroke recovery through effects in angiogenesis, neurogenesis, and neuroprotection. METHODS: We tested the association of variants in the brain-derived neurotrophic factor (BDNF), fibroblast growth factor 2 (FGF2) and vascular endothelial growth factor A (VEGFA) genes, and epistatic interactions between them, with functional outcome in a sample of 546 strokepatients. RESULTS: While none of the tested genes was independently associated with stroke outcome, two significant gene-gene interaction models were identified. One model combined one BDNF and three FGF2 markers, with a global odds ratio (OR) (95% confidence interval [CI]) of 4.15 [2.86-6.04]. The second model included one FGF2 and two VEGFA markers with a global OR [95% CI] = 2.54 [1.76-3.67]. CONCLUSIONS: The results provide evidence for gene interactions in stroke outcome, highlighting the complexity of the recovery mechanisms after a stroke event.
Authors: Tara M Stanne; Anna Tjärnlund-Wolf; Sandra Olsson; Katarina Jood; Christian Blomstrand; Christina Jern Journal: PLoS One Date: 2014-12-03 Impact factor: 3.240
Authors: Christine T Shiner; Kerrie D Pierce; Angelica G Thompson-Butel; Terry Trinh; Peter R Schofield; Penelope A McNulty Journal: Front Neurol Date: 2016-05-17 Impact factor: 4.003
Authors: Vincenzo Di Lazzaro; Giovanni Pellegrino; Giovanni Di Pino; Marzia Corbetto; Federico Ranieri; Nicoletta Brunelli; Matteo Paolucci; Serena Bucossi; Maria C Ventriglia; Peter Brown; Fioravante Capone Journal: Brain Stimul Date: 2014-08-23 Impact factor: 8.955