Literature DB >> 22232260

Lupeol supplementation improves blood pressure and lipid metabolism parameters in stroke-prone spontaneously hypertensive rats.

Eri Yamaguchi, Hitoshi Shirakawa, Keishi Hata, Kazuyuki Hiwatashi, Kousaku Ohinata, Tomoko Goto, Michio Komai.   

Abstract

Supplementation with lupeol (0.67 g·kg(-1)) of the AIN-93M-based diet fed for 7 weeks to stroke-prone spontaneously hypertensive rats caused significantly decreased blood pressure as compared with a control group. Urinary 8-hydroxy-2'-deoxyguanosine was significantly lower in the lupeol group. Finally, lupeol suppressed the hepatic mRNA expression levels of the genes involved in triglyceride and cholesterol synthesis.

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Year:  2012        PMID： 22232260     DOI： 10.1271/bbb.110559

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  8 in total

1.  Activity-guided purification identifies lupeol, a pentacyclic triterpene, as a therapeutic agent multiple pathogenic factors of acne.

Authors:  Hyuck Hoon Kwon; Ji Young Yoon; Seon Yong Park; Seonguk Min; Yong-Il Kim; Ji Yong Park; Yun-Sang Lee; Diane M Thiboutot; Dae Hun Suh
Journal:  J Invest Dermatol       Date:  2015-02-03       Impact factor: 8.551

2.  Lupeol enhances inhibitory effect of 5-fluorouracil on human gastric carcinoma cells.

Authors:  Yan Liu; Tingting Bi; Wei Dai; Gang Wang; Liqiang Qian; Genhai Shen; Quangen Gao
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2016-02-19       Impact factor: 3.000

3.  Lupeol inhibits proliferation and induces apoptosis of human pancreatic cancer PCNA-1 cells through AKT/ERK pathways.

Authors:  Yan Liu; Tingting Bi; Gang Wang; Wei Dai; Guoliang Wu; Liqiang Qian; Quangen Gao; Genhai Shen
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2014-11-25       Impact factor: 3.000

4.  Lupeol induces apoptosis and inhibits invasion in gallbladder carcinoma GBC-SD cells by suppression of EGFR/MMP-9 signaling pathway.

Authors:  Yan Liu; Tingting Bi; Genhai Shen; Zhimin Li; Guoliang Wu; Zheng Wang; Liqiang Qian; Quangen Gao
Journal:  Cytotechnology       Date:  2014-07-19       Impact factor: 2.058

5.  Lupeol synergizes with doxorubicin to induce anti-proliferative and apoptotic effects on breast cancer cells.

Authors:  Faezeh Malekinejad; Fatemeh Kheradmand; Mohammad Hassan Khadem-Ansari; Hassan Malekinejad
Journal:  Daru       Date:  2022-02-03       Impact factor: 4.088

6.  The effect of hydroalcoholic extract from the leaves of Moringa peregrina (Forssk.) Fiori. on blood pressure and oxidative status in dexamethasone-induced hypertensive rats.

Authors:  Leila Safaeian; Gholamreza Asghari; Shaghayegh Haghjoo Javanmard; Arman Heidarinejad
Journal:  Adv Biomed Res       Date:  2015-05-11

7.  Molecular Regulation of α3β4 Nicotinic Acetylcholine Receptors by Lupeol in Cardiovascular System.

Authors:  Sanung Eom; Chaelin Kim; Hye Duck Yeom; Jaeeun Lee; Shinhui Lee; Yeong-Bin Baek; Jinseong Na; Sang-Ik Park; Gye-Yeop Kim; Chang-Min Lee; Jun-Ho Lee
Journal:  Int J Mol Sci       Date:  2020-06-18       Impact factor: 5.923

8.  Lupeol, a Pentacyclic Triterpene, Promotes Migration, Wound Closure, and Contractile Effect In Vitro: Possible Involvement of PI3K/Akt and p38/ERK/MAPK Pathways.

Authors:  Fernando Pereira Beserra; Meilang Xue; Gabriela Lemos de Azevedo Maia; Ariane Leite Rozza; Cláudia Helena Pellizzon; Christopher John Jackson
Journal:  Molecules       Date:  2018-10-30       Impact factor: 4.411
  8 in total

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