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Literature DB >> 22231719

NSAIDs in the treatment and/or prevention of neurological disorders.

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) have been used extensively in the treatment of inflammatory disorders and pain. In recent years, emerging data suggest that some NSAIDs possess pharmacological properties, in addition to cyclooxygenase inhibition, which may be beneficial in the treatment of several neurological conditions. For example, fenamate NSAIDs potentiate GABA-A receptor function, indomethacin scavenges nitric oxide free radicals, and acetylsalicylic acid inhibits the translocation of NF-κB, all of which may contribute to their neuroprotective actions in selected experimental models of stroke. The purpose of this review is to explore the diverse pharmacological properties of NSAIDs in relation to their potential value in the treatment of selected neurological diseases.

Entities: Chemical Disease Gene

Mesh：

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Year: 2012 PMID： 22231719 DOI： 10.1007/s10787-011-0116-2

Source DB: PubMed Journal: Inflammopharmacology ISSN： 0925-4692 Impact factor: 4.473

90 in total

1. Inflammatory response after ischemic stroke: a USPIO-enhanced MRI study in patients.

Authors: Norbert Nighoghossian; Marlène Wiart; Serkan Cakmak; Yves Berthezène; Laurent Derex; Tae-Hee Cho; Chantal Nemoz; François Chapuis; Guy-Louis Tisserand; Jean-Baptiste Pialat; Paul Trouillas; Jean-Claude Froment; Marc Hermier
Journal: Stroke Date: 2006-12-14 Impact factor: 7.914

Review 2. Molecular mechanisms of nigral neurodegeneration in Park2 and regulation of parkin protein by other proteins.

Authors: N Hattori; Y Machida; S Sato; K Noda; M Iijima-Kitami; S Kubo; Y Mizuno
Journal: J Neural Transm Suppl Date: 2006

Review 3. Alzheimer's disease.

Authors: Henry W Querfurth; Frank M LaFerla
Journal: N Engl J Med Date: 2010-01-28 Impact factor: 91.245

4. Evidence for neuroprotection by the fenamate NSAID, mefenamic acid.

Authors: Parto S Khansari; Robert F Halliwell
Journal: Neurochem Int Date: 2009-06-27 Impact factor: 3.921

Review 5. On the relation of oxidative stress to neuroinflammation: lessons learned from the G93A-SOD1 mouse model of amyotrophic lateral sclerosis.

Authors: Kenneth Hensley; Molina Mhatre; Shenyun Mou; Quentin N Pye; Charles Stewart; Melinda West; Kelly S Williamson
Journal: Antioxid Redox Signal Date: 2006 Nov-Dec Impact factor: 8.401

Review 6. Neuronal damage in brain inflammation.

Authors: Orhan Aktas; Oliver Ullrich; Carmen Infante-Duarte; Robert Nitsch; Frauke Zipp
Journal: Arch Neurol Date: 2007-02

7. Delayed treatment with nimesulide reduces measures of oxidative stress following global ischemic brain injury in gerbils.

Authors: Eduardo Candelario-Jalil; Dalia Alvarez; Nelson Merino; Olga Sonia León
Journal: Neurosci Res Date: 2003-10 Impact factor: 3.304

8. Ibuprofen reduces Abeta, hyperphosphorylated tau and memory deficits in Alzheimer mice.

Authors: Ann C McKee; Isabel Carreras; Lokman Hossain; Hoon Ryu; William L Klein; Salvatore Oddo; Frank M LaFerla; Bruce G Jenkins; Neil W Kowall; Alpaslan Dedeoglu
Journal: Brain Res Date: 2008-02-16 Impact factor: 3.252

Review 9. Multifunctional actions of approved and candidate stroke drugs.

Authors: Jens Minnerup; Wolf-Rüdiger Schäbitz
Journal: Neurotherapeutics Date: 2009-01 Impact factor: 7.620

10. Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase.

Authors: Magdalena Sastre; Ilse Dewachter; Gary E Landreth; Timothy M Willson; Thomas Klockgether; Fred van Leuven; Michael T Heneka
Journal: J Neurosci Date: 2003-10-29 Impact factor: 6.167

3 in total