Literature DB >> 22231456

Efficient synthesis of multicyclic spirooxindoles via a cascade Michael/Michael/oxa-Michael reaction of curcumins and isatylidene malononitriles.

Xiao-Gang Yin1, Xin-Yun Liu, Zhi-Peng Hu, Ming Yan.   

Abstract

A cascade Michael/Michael/oxa-Michael reaction between curcumins and isatylidene malononitriles has been developed. Multicyclic spirooxindoles were prepared in excellent yields and diastereoselectivities. DMAP was found to catalyze this transformation efficiently under mild reaction conditions.

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Year:  2012        PMID： 22231456     DOI： 10.1039/c2ob06995d

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  2 in total

1.  Synthesis of a Library of 1,5,2-Dithiazepine 1,1-Dioxides. Part 1: A One-Pot Sulfonylation/Thia-Michael Protocol.

Authors:  Qin Zang; Aihua Zhou; Salim Javed; Pradip K Maity; Chris A Knudtson; Danse Bi; Jared J Hastings; Fatima Z Basha; Paul R Hanson
Journal:  Heterocycles       Date:  2012-12-31       Impact factor: 0.831

2.  Expanding the chemical diversity of spirooxindoles via alkylative pyridine dearomatization.

Authors:  Chunhui Dai; Bo Liang; Corey R J Stephenson
Journal:  Beilstein J Org Chem       Date:  2012-07-02       Impact factor: 2.883
  2 in total

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