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Literature DB >> 22231116

Transcriptional regulation of Rho GTPase signaling.

Abstract

Signaling through the Rho family of small GTPases regulates a variety of cellular processes via changes in the actin cytoskeleton. Here we discuss recent findings that show the transcription factor p53 regulates the expression of several Rho pathway signaling molecules, and how mutation of p53 in cancer dramatically alters signaling output through this pathway.

Entities: Disease Gene

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Year: 2011 PMID： 22231116 PMCID： PMC3265777 DOI： 10.4161/trns.2.5.16904

Source DB: PubMed Journal: Transcription ISSN： 2154-1272

30 in total

Review 1. RHO-GTPases and cancer.

Authors: Erik Sahai; Christopher J Marshall
Journal: Nat Rev Cancer Date: 2002-02 Impact factor: 60.716

Review 2. Rho GTPases: biochemistry and biology.

Authors: Aron B Jaffe; Alan Hall
Journal: Annu Rev Cell Dev Biol Date: 2005 Impact factor: 13.827

3. RhoE is a pro-survival p53 target gene that inhibits ROCK I-mediated apoptosis in response to genotoxic stress.

Authors: Pat P Ongusaha; Hyung-Gu Kim; Sarah A Boswell; Anne J Ridley; Channing J Der; G Paolo Dotto; Young-Bum Kim; Stuart A Aaronson; Sam W Lee
Journal: Curr Biol Date: 2006-12-19 Impact factor: 10.834

4. The activation of p38 MAPK primarily contributes to UV-induced RhoB expression by recruiting the c-Jun and p300 to the distal CCAAT box of the RhoB promoter.

Authors: Jiwon Ahn; Jeong-Hae Choi; Misun Won; Chang-Mo Kang; Mi-Rang Gyun; Hee-Moon Park; Chun-Ho Kim; Kyung-Sook Chung
Journal: Biochem Biophys Res Commun Date: 2011-05-03 Impact factor: 3.575

5. Mutant p53 induces the GEF-H1 oncogene, a guanine nucleotide exchange factor-H1 for RhoA, resulting in accelerated cell proliferation in tumor cells.

Authors: Shinji Mizuarai; Kazunori Yamanaka; Hidehito Kotani
Journal: Cancer Res Date: 2006-06-15 Impact factor: 12.701

6. Tumor suppressor p53 restricts Ras stimulation of RhoA and cancer cell motility.

Authors: Mingxuan Xia; Hartmut Land
Journal: Nat Struct Mol Biol Date: 2007-02-18 Impact factor: 15.369

7. Tumour invasion and metastasis initiated by microRNA-10b in breast cancer.

Authors: Li Ma; Julie Teruya-Feldstein; Robert A Weinberg
Journal: Nature Date: 2007-09-26 Impact factor: 49.962

8. Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases.

Authors: Karine Lefort; Anna Mandinova; Paola Ostano; Vihren Kolev; Valerie Calpini; Ingrid Kolfschoten; Vikram Devgan; Jocelyn Lieb; Wassim Raffoul; Daniel Hohl; Victor Neel; Jonathan Garlick; Giovanna Chiorino; G Paolo Dotto
Journal: Genes Dev Date: 2007-03-01 Impact factor: 11.361

9. Actin-myosin-based contraction is responsible for apoptotic nuclear disintegration.

Authors: Daniel R Croft; Mathew L Coleman; Shuixing Li; David Robertson; Teresa Sullivan; Colin L Stewart; Michael F Olson
Journal: J Cell Biol Date: 2005-01-17 Impact factor: 10.539

10. Loss of p53 promotes RhoA-ROCK-dependent cell migration and invasion in 3D matrices.

Authors: Gilles Gadea; Marion de Toledo; Christelle Anguille; Pierre Roux
Journal: J Cell Biol Date: 2007-07-02 Impact factor: 10.539

13 in total

Review 1. Pathophysiological Functions of Rnd3/RhoE.

Authors: Wei Jie; Kelsey C Andrade; Xi Lin; Xiangsheng Yang; Xiaojing Yue; Jiang Chang
Journal: Compr Physiol Date: 2015-12-15 Impact factor: 9.090

2. p53 protects against LPS-induced lung endothelial barrier dysfunction.

Authors: Nektarios Barabutis; Christiana Dimitropoulou; Charalampos Birmpas; Atul Joshi; Gagan Thangjam; John D Catravas
Journal: Am J Physiol Lung Cell Mol Physiol Date: 2015-02-20 Impact factor: 5.464

Review 3. Regulating Rho GTPases and their regulators.

Authors: Richard G Hodge; Anne J Ridley
Journal: Nat Rev Mol Cell Biol Date: 2016-06-15 Impact factor: 94.444

Review 4. Cell cycle regulation of Rho signaling pathways.

Authors: Muriel David; Dominique Petit; Jacques Bertoglio
Journal: Cell Cycle Date: 2012-07-24 Impact factor: 4.534

Review 5. p53 in cell invasion, podosomes, and invadopodia.

Authors: Alan S Mak
Journal: Cell Adh Migr Date: 2014 Impact factor: 3.405

6. Activation of the RhoB signaling pathway by thyroid hormone receptor β in thyroid cancer cells.

Authors: Sayaka Ichijo; Fumihiko Furuya; Hiroki Shimura; Yoshitaka Hayashi; Kazuya Takahashi; Kazuyasu Ohta; Tetsuro Kobayashi; Kenichiro Kitamura
Journal: PLoS One Date: 2014-12-30 Impact factor: 3.240

7. Diallyl disulfide inhibits colon cancer metastasis by suppressing Rac1-mediated epithelial-mesenchymal transition.

Authors: Longzheng Xia; Jingguan Lin; Jian Su; Linda Oyang; Heran Wang; Shiming Tan; Yanyan Tang; Xiaoyan Chen; Wenbin Liu; Xia Luo; Yutong Tian; Jiaxin Liang; Qi Su; Qianjin Liao; Yujuan Zhou
Journal: Onco Targets Ther Date: 2019-07-16 Impact factor: 4.147