Literature DB >> 22230611

Design and characterization of antitumor drug paclitaxel-loaded chitosan nanoparticles by W/O emulsions.

Juan Xu1, Lili Ma, Yang Liu, Fei Xu, Jun Nie, Guiping Ma.   

Abstract

Chitosan nanoparticles and paclitaxel loaded chitosan nanoparticles were prepared by emulsification-crosslinking method in a W/O emulsion system, using glutaraldehyde as crosslinking agent. The mean diameter of chitosan nanoparticles decreased with increase of pH value of the reaction system from 4.5 to 6.5, and increased when the pH exceeded 6.5. Ultraviolet spectrum analysis showed that the largest loading efficiency and encapsulation efficiency could be 8.55% and 94.01%, respectively. In vitro drug release profile was also determined by ultraviolet spectrometry. MTT assays revealed that the blank chitosan nanoparticles had almost none toxicity, and cell culture was carried out accordingly.
Copyright © 2012 Elsevier B.V. All rights reserved.

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Year:  2012        PMID： 22230611     DOI： 10.1016/j.ijbiomac.2011.12.034

Source DB:  PubMed          Journal:  Int J Biol Macromol        ISSN： 0141-8130            Impact factor:   6.953


  9 in total

1.  pH- and Ultrasound-Responsive Paclitaxel-Loaded Carboxymethyl Chitosan Nanodroplets for Combined Imaging and Synergistic Chemoradiotherapy.

Authors:  Mengmeng Shang; Xiao Sun; Lu Guo; Dandan Shi; Ping Liang; Dong Meng; Xiaoying Zhou; Xinxin Liu; Yading Zhao; Jie Li
Journal:  Int J Nanomedicine       Date:  2020-01-24

2.  Biocompatibility of chitosan carriers with application in drug delivery.

Authors:  Susana Rodrigues; Marita Dionísio; Carmen Remuñán López; Ana Grenha
Journal:  J Funct Biomater       Date:  2012-09-17

3.  Improving antitumor outcomes for palliative intratumoral injection therapy through lecithin- chitosan nanoparticles loading paclitaxel- cholesterol complex.

Authors:  Xiao-Yang Chu; Wei Huang; Yu-Li Wang; Ling-Wei Meng; Li-Qing Chen; Ming-Ji Jin; Lu Chen; Chun-Hong Gao; Cheng Ge; Zhong-Gao Gao; Chun-Sheng Gao
Journal:  Int J Nanomedicine       Date:  2019-01-23

4.  PEGylated Chitosan Nanoparticles Encapsulating Ascorbic Acid and Oxaliplatin Exhibit Dramatic Apoptotic Effects against Breast Cancer Cells.

Authors:  Sherif Ashraf Fahmy; Asmaa Ramzy; Asmaa A Mandour; Soad Nasr; Anwar Abdelnaser; Udo Bakowsky; Hassan Mohamed El-Said Azzazy
Journal:  Pharmaceutics       Date:  2022-02-13       Impact factor: 6.321

5.  Synthesis of glycyrrhetinic acid-modified chitosan 5-fluorouracil nanoparticles and its inhibition of liver cancer characteristics in vitro and in vivo.

Authors:  Mingrong Cheng; Xiaoyan Gao; Yong Wang; Houxiang Chen; Bing He; Hongzhi Xu; Yingchun Li; Jiang Han; Zhiping Zhang
Journal:  Mar Drugs       Date:  2013-09-17       Impact factor: 5.118

6.  Glycyrrhetinic acid-modified chitosan nanoparticles enhanced the effect of 5-fluorouracil in murine liver cancer model via regulatory T-cells.

Authors:  Mingrong Cheng; Hongzhi Xu; Yong Wang; Houxiang Chen; Bing He; Xiaoyan Gao; Yingchun Li; Jiang Han; Zhiping Zhang
Journal:  Drug Des Devel Ther       Date:  2013-10-25       Impact factor: 4.162

7.  Optimized synthesis of glycyrrhetinic acid-modified chitosan 5-fluorouracil nanoparticles and their characteristics.

Authors:  Mingrong Cheng; Houxiang Chen; Yong Wang; Hongzhi Xu; Bing He; Jiang Han; Zhiping Zhang
Journal:  Int J Nanomedicine       Date:  2014-01-24

Review 8.  "The Good, the Bad and the Ugly" of Chitosans.

Authors:  Barbara Bellich; Ilenia D'Agostino; Sabrina Semeraro; Amelia Gamini; Attilio Cesàro
Journal:  Mar Drugs       Date:  2016-05-17       Impact factor: 5.118

Review 9.  Chitosan Nanoparticle-Based System: A New Insight into the Promising Controlled Release System for Lung Cancer Treatment.

Authors:  Cha Yee Kuen; Mas Jaffri Masarudin
Journal:  Molecules       Date:  2022-01-12       Impact factor: 4.411
  9 in total

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