| Literature DB >> 22230325 |
H-Q Qu1, A R Rentfro, Y Lu, S Nair, C L Hanis, J B McCormick, S P Fisher-Hoch.
Abstract
Tuberculosis (TB) remains a major global disease, and diabetes, which is documented to increase susceptibility to TB threefold, is also becoming pandemic. This susceptibility has been attracting extensive research interest. The increased risk of TB in diabetes may serve as a unique model to understand host susceptibility to specific pathogens in humans. To examine this rationale, we investigated the expression of reported TB candidate genes in a longitudinal diabetes study. Two genes, HK2 and CD28, emerged as potential culprits in diabetes-increased TB susceptibility.Entities:
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Year: 2012 PMID: 22230325 PMCID: PMC3342484 DOI: 10.5588/ijtld.11.0536
Source DB: PubMed Journal: Int J Tuberc Lung Dis ISSN: 1027-3719 Impact factor: 2.373