AIM: To investigate appropriate therapeutic strategies for graft-vs-host disease (GVHD) following liver transplantation. METHODS: Four patients who developed GVHD after liver transplantation in West China Hospital were included in this study. Therapeutic strategies with augmentation or withdrawal of immunosuppressants combined with supportive therapy were investigated in these patients. In addition, a literature review of patients who developed GVHD after liver transplantation was performed. RESULTS: Although a transient response to initial treatment was detected, all four patients died of complications from GVHD: one from sepsis with multiple organ failure, one from gastrointestinal bleeding, and the other two from sepsis with gastrointestinal bleeding. Few consensuses for the treatment of GVHD after liver transplantation have been reached. CONCLUSION: New and effective treatments are required for GVHD after liver transplantation to improve the prognosis of patients with this diagnosis.
AIM: To investigate appropriate therapeutic strategies for graft-vs-host disease (GVHD) following liver transplantation. METHODS: Four patients who developed GVHD after liver transplantation in West China Hospital were included in this study. Therapeutic strategies with augmentation or withdrawal of immunosuppressants combined with supportive therapy were investigated in these patients. In addition, a literature review of patients who developed GVHD after liver transplantation was performed. RESULTS: Although a transient response to initial treatment was detected, all four patients died of complications from GVHD: one from sepsis with multiple organ failure, one from gastrointestinal bleeding, and the other two from sepsis with gastrointestinal bleeding. Few consensuses for the treatment of GVHD after liver transplantation have been reached. CONCLUSION: New and effective treatments are required for GVHD after liver transplantation to improve the prognosis of patients with this diagnosis.
Authors: F Lehner; T Becker; L Sybrecht; R Lück; R Schwinzer; K Slateva; R Blasczyk; B Hertenstein; J Klempnauer; B Nashan Journal: Transplantation Date: 2002-01-27 Impact factor: 4.939
Authors: J F Burdick; G B Vogelsang; W J Smith; E R Farmer; W B Bias; S H Kaufmann; J Horn; P M Colombani; H A Pitt; B A Perler Journal: N Engl J Med Date: 1988-03-17 Impact factor: 91.245
Authors: S Norris; C Collins; D G Doherty; F Smith; G McEntee; O Traynor; N Nolan; J Hegarty; C O'Farrelly Journal: J Hepatol Date: 1998-01 Impact factor: 25.083
Authors: Douglas M Smith; Edward Agura; George Netto; Robert Collins; Marlon Levy; Robert Goldstein; Laura Christensen; Judy Baker; Basel Altrabulsi; Lori Osowski; Jeff McCormack; Lisa Fichtel; D Brian Dawson; Rana Domiati-Saad; Marvin Stone; Goran Klintmalm Journal: Transplantation Date: 2003-01-15 Impact factor: 4.939
Authors: Anna L Taylor; Paul Gibbs; Surendran Sudhindran; Tim Key; Reyna S Goodman; C Helen Morgan; Christopher J E Watson; Luc Delriviere; Graeme J Alexander; Neville V Jamieson; J Andrew Bradley; Craig J Taylor Journal: Transplantation Date: 2004-02-15 Impact factor: 4.939
Authors: Arvind R Murali; Subhash Chandra; Zoe Stewart; Bruce R Blazar; Umar Farooq; M Nedim Ince; Jeffrey Dunkelberg Journal: Transplantation Date: 2016-12 Impact factor: 4.939
Authors: Joanna Raszeja-Wyszomirska; Michał P Wasilewicz; Monika Szydłowska-Jakimiuk; Ireneusz Grzelak; Wojciech Figiel; Wojciech Sachs; Grzegorz Niewiński; Beata Gierej; Bogna Ziarkiewicz-Wróblewska; Marek Krawczyk Journal: Prz Gastroenterol Date: 2015-06-26