Literature DB >> 22228324

Organocatalytic asymmetric synthesis of 3-difluoroalkyl 3-hydroxyoxindoles.

Yun-Lin Liu1, Jian Zhou.   

Abstract

We report the first example of highly enantioselective organocatalytic synthesis of 3-difluoroalkyl substituted 3-hydroxyoxindoles. The total synthesis of the difluoro analogue of convolutamydine E was achieved by this method. This journal is © The Royal Society of Chemistry 2012

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Year:  2012        PMID： 22228324     DOI： 10.1039/c2cc17140f

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  6 in total

1.  Regio- and Enantioselective Bromocyclization of Difluoroalkenes as a Strategy to Access Tetrasubstituted Difluoromethylene-Containing Stereocenters.

Authors:  Edward Miller; Suhong Kim; Katarina Gibson; Jeffrey S Derrick; F Dean Toste
Journal:  J Am Chem Soc       Date:  2020-04-30       Impact factor: 15.419

2.  Metal-catalyzed Decarboxylative Fluoroalkylation Reactions.

Authors:  Brett R Ambler; Ming-Hsiu Yang; Ryan A Altman
Journal:  Synlett       Date:  2016-12       Impact factor: 2.454

3.  Conversion of Methyl Ketones and Methyl Sulfones into α-Deutero-α,α-Difluoromethyl Ketones and α-Deutero-α,α-Difluoromethyl Sulfones in Three Synthetic Steps.

Authors:  Munia F Sowaileh; Changho Han; Robert A Hazlitt; Eun Hoo Kim; Jinu P John; David A Colby
Journal:  Tetrahedron Lett       Date:  2016-12-21       Impact factor: 2.415

4.  Tailoring Tryptophan Synthase TrpB for Selective Quaternary Carbon Bond Formation.

Authors:  Markus Dick; Nicholas S Sarai; Michael W Martynowycz; Tamir Gonen; Frances H Arnold
Journal:  J Am Chem Soc       Date:  2019-12-06       Impact factor: 15.419

5.  Palladium Catalysis Enables Benzylation of α,α-Difluoroketone Enolates.

Authors:  Ming-Hsiu Yang; Jordan R Hunt; Niusha Sharifi; Ryan A Altman
Journal:  Angew Chem Int Ed Engl       Date:  2016-06-17       Impact factor: 15.336

6.  A convenient approach to difluoromethylated all-carbon quaternary centers via Ni(ii)-catalyzed enantioselective Michael addition.

Authors:  Xuan Yu; Hui Bai; Dong Wang; Zhaohai Qin; Jia-Qi Li; Bin Fu
Journal:  RSC Adv       Date:  2018-05-25       Impact factor: 3.361
  6 in total

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