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Literature DB >> 22227487

Polymorphisms in inflammasome' genes and susceptibility to HIV-1 infection.

Alessandra Pontillo¹, Telma M Oshiro, Martina Girardelli, Anselmo J Kamada, Sergio Crovella, Alberto J S Duarte.

Abstract

The involvement of inflammasome genes in the susceptibility to HIV-1 infection was investigated. Twelve single nucleotide polymorphisms within NLRP1, NLRP3, NLRC4, CARD8, CASP1, and IL1B genes were analyzed in 150 HIV-1-infected Brazilian subjects and 158 healthy controls. The 2 polymorphisms rs10754558 in NLRP3 and rs1143634 in IL1B were significantly associated to the HIV-1 infection. These findings supported the previously hypothesized involvement of NALP3-inflammasome in HIV-1 pathogenesis, underlining once more the key role of inflammation and innate immunity in the susceptibility to HIV-1 infection.

Entities: Disease Gene Mutation Species

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Year: 2012 PMID： 22227487 DOI： 10.1097/QAI.0b013e3182392ebe

Source DB: PubMed Journal: J Acquir Immune Defic Syndr ISSN： 1525-4135 Impact factor: 3.731

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Cited

32 in total

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