Literature DB >> 22226782

Presence of somatic mutations in most early-stage pancreatic intraepithelial neoplasia.

Mitsuro Kanda1, Hanno Matthaei, Jian Wu, Seung-Mo Hong, Jun Yu, Michael Borges, Ralph H Hruban, Anirban Maitra, Kenneth Kinzler, Bert Vogelstein, Michael Goggins.   

Abstract

More information is needed about genetic factors that initiate development of pancreatic intraepithelial neoplasms-the most common precursors of pancreatic ductal adenocarcinoma. We show that more than 99% of the earliest-stage, lowest-grade, pancreatic intraepithelial neoplasm-1 lesions contain mutations in KRAS, p16/CDKN2A, GNAS, or BRAF. These findings could improve our understanding of the development and progression of these premalignant lesions.
Copyright © 2012 AGA Institute. Published by Elsevier Inc. All rights reserved.

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Year:  2012        PMID： 22226782      PMCID： PMC3321090          DOI： 10.1053/j.gastro.2011.12.042

Source DB:  PubMed          Journal:  Gastroenterology        ISSN： 0016-5085            Impact factor:   22.682


  14 in total

Review 1.  Progression model for pancreatic cancer.

Authors:  R H Hruban; M Goggins; J Parsons; S E Kern
Journal:  Clin Cancer Res       Date:  2000-08       Impact factor: 12.531

Review 2.  When cells get stressed: an integrative view of cellular senescence.

Authors:  Ittai Ben-Porath; Robert A Weinberg
Journal:  J Clin Invest       Date:  2004-01       Impact factor: 14.808

3.  Frequency of K-ras mutations in pancreatic intraductal neoplasias associated with pancreatic ductal adenocarcinoma and chronic pancreatitis: a meta-analysis.

Authors:  Matthias Löhr; Günter Klöppel; Patrick Maisonneuve; Albert B Lowenfels; Jutta Lüttges
Journal:  Neoplasia       Date:  2005-01       Impact factor: 5.715

4.  Genome-wide analysis of promoter methylation associated with gene expression profile in pancreatic adenocarcinoma.

Authors:  Audrey Vincent; Noriyuki Omura; Seung-Mo Hong; Andrew Jaffe; James Eshleman; Michael Goggins
Journal:  Clin Cancer Res       Date:  2011-05-24       Impact factor: 12.531

5.  Increased Prevalence of Precursor Lesions in Familial Pancreatic Cancer Patients.

Authors:  Chanjuan Shi; Alison P Klein; Michael Goggins; Anirban Maitra; Marcia Canto; Syed Ali; Richard Schulick; Emily Palmisano; Ralph H Hruban
Journal:  Clin Cancer Res       Date:  2009-12-15       Impact factor: 12.531

Review 6.  Pancreatic cancer.

Authors:  Audrey Vincent; Joseph Herman; Rich Schulick; Ralph H Hruban; Michael Goggins
Journal:  Lancet       Date:  2011-05-26       Impact factor: 79.321

7.  Recurrent GNAS mutations define an unexpected pathway for pancreatic cyst development.

Authors:  Jian Wu; Hanno Matthaei; Anirban Maitra; Marco Dal Molin; Laura D Wood; James R Eshleman; Michael Goggins; Marcia I Canto; Richard D Schulick; Barish H Edil; Christopher L Wolfgang; Alison P Klein; Luis A Diaz; Peter J Allen; C Max Schmidt; Kenneth W Kinzler; Nickolas Papadopoulos; Ralph H Hruban; Bert Vogelstein
Journal:  Sci Transl Med       Date:  2011-07-20       Impact factor: 17.956

8.  Gene expression profiles in pancreatic intraepithelial neoplasia reflect the effects of Hedgehog signaling on pancreatic ductal epithelial cells.

Authors:  Nijaguna B Prasad; Andrew V Biankin; Noriyoshi Fukushima; Anirban Maitra; Surajit Dhara; Abdel G Elkahloun; Ralph H Hruban; Michael Goggins; Steven D Leach
Journal:  Cancer Res       Date:  2005-03-01       Impact factor: 12.701

9.  Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse.

Authors:  Sunil R Hingorani; Emanuel F Petricoin; Anirban Maitra; Vinodh Rajapakse; Catrina King; Michael A Jacobetz; Sally Ross; Thomas P Conrads; Timothy D Veenstra; Ben A Hitt; Yoshiya Kawaguchi; Don Johann; Lance A Liotta; Howard C Crawford; Mary E Putt; Tyler Jacks; Christopher V E Wright; Ralph H Hruban; Andrew M Lowy; David A Tuveson
Journal:  Cancer Cell       Date:  2003-12       Impact factor: 31.743

10.  Core signaling pathways in human pancreatic cancers revealed by global genomic analyses.

Authors:  Siân Jones; Xiaosong Zhang; D Williams Parsons; Jimmy Cheng-Ho Lin; Rebecca J Leary; Philipp Angenendt; Parminder Mankoo; Hannah Carter; Hirohiko Kamiyama; Antonio Jimeno; Seung-Mo Hong; Baojin Fu; Ming-Tseh Lin; Eric S Calhoun; Mihoko Kamiyama; Kimberly Walter; Tatiana Nikolskaya; Yuri Nikolsky; James Hartigan; Douglas R Smith; Manuel Hidalgo; Steven D Leach; Alison P Klein; Elizabeth M Jaffee; Michael Goggins; Anirban Maitra; Christine Iacobuzio-Donahue; James R Eshleman; Scott E Kern; Ralph H Hruban; Rachel Karchin; Nickolas Papadopoulos; Giovanni Parmigiani; Bert Vogelstein; Victor E Velculescu; Kenneth W Kinzler
Journal:  Science       Date:  2008-09-04       Impact factor: 47.728
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  276 in total

Review 1.  Genetically Engineered Mouse Models of K-Ras-Driven Lung and Pancreatic Tumors: Validation of Therapeutic Targets.

Authors:  Matthias Drosten; Carmen Guerra; Mariano Barbacid
Journal:  Cold Spring Harb Perspect Med       Date:  2018-05-01       Impact factor: 6.915

2.  Genome-wide somatic copy number alterations in low-grade PanINs and IPMNs from individuals with a family history of pancreatic cancer.

Authors:  Seung-Mo Hong; Audrey Vincent; Mitsuro Kanda; Julie Leclerc; Noriyuki Omura; Michael Borges; Alison P Klein; Marcia Irene Canto; Ralph H Hruban; Michael Goggins
Journal:  Clin Cancer Res       Date:  2012-06-21       Impact factor: 12.531

3.  High-content, full genome siRNA screen for regulators of oncogenic HRAS-driven macropinocytosis.

Authors:  Myles Fennell; Cosimo Commisso; Craig Ramirez; Ralph Garippa; Dafna Bar-Sagi
Journal:  Assay Drug Dev Technol       Date:  2015-08-12       Impact factor: 1.738

4.  Hif1a Deletion Reveals Pro-Neoplastic Function of B Cells in Pancreatic Neoplasia.

Authors:  Kyoung Eun Lee; Michelle Spata; Lauren J Bayne; Elizabeth L Buza; Amy C Durham; David Allman; Robert H Vonderheide; M Celeste Simon
Journal:  Cancer Discov       Date:  2015-12-29       Impact factor: 39.397

5.  Mutational spectrum of intraepithelial neoplasia in pancreatic heterotopia.

Authors:  Changqing Ma; Christopher D Gocke; Ralph H Hruban; Deborah A Belchis
Journal:  Hum Pathol       Date:  2015-10-09       Impact factor: 3.466

6.  A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.

Authors:  Olca Basturk; Seung-Mo Hong; Laura D Wood; N Volkan Adsay; Jorge Albores-Saavedra; Andrew V Biankin; Lodewijk A A Brosens; Noriyoshi Fukushima; Michael Goggins; Ralph H Hruban; Yo Kato; David S Klimstra; Günter Klöppel; Alyssa Krasinskas; Daniel S Longnecker; Hanno Matthaei; G Johan A Offerhaus; Michio Shimizu; Kyoichi Takaori; Benoit Terris; Shinichi Yachida; Irene Esposito; Toru Furukawa
Journal:  Am J Surg Pathol       Date:  2015-12       Impact factor: 6.394

7.  GNAS sequencing identifies IPMN-specific mutations in a subgroup of diminutive pancreatic cysts referred to as "incipient IPMNs".

Authors:  Hanno Matthaei; Jian Wu; Marco Dal Molin; Chanjuan Shi; Sven Perner; Glen Kristiansen; Philipp Lingohr; Jörg C Kalff; Christopher L Wolfgang; Kenneth W Kinzler; Bert Vogelstein; Anirban Maitra; Ralph H Hruban
Journal:  Am J Surg Pathol       Date:  2014-03       Impact factor: 6.394

8.  Diversity of clinical implication of B-cell translocation gene 1 expression by histopathologic and anatomic subtypes of gastric cancer.

Authors:  Mitsuro Kanda; Hisaharu Oya; Shuji Nomoto; Hideki Takami; Dai Shimizu; Ryoji Hashimoto; Satoshi Sueoka; Daisuke Kobayashi; Chie Tanaka; Suguru Yamada; Tsutomu Fujii; Goro Nakayama; Hiroyuki Sugimoto; Masahiko Koike; Michitaka Fujiwara; Yasuhiro Kodera
Journal:  Dig Dis Sci       Date:  2014-12-09       Impact factor: 3.199

9.  KRAS and guanine nucleotide-binding protein mutations in pancreatic juice collected from the duodenum of patients at high risk for neoplasia undergoing endoscopic ultrasound.

Authors:  James R Eshleman; Alexis L Norris; Yoshihiko Sadakari; Marija Debeljak; Michael Borges; Colleen Harrington; Elaine Lin; Aaron Brant; Thomas Barkley; J Alejandro Almario; Mark Topazian; James Farrell; Sapna Syngal; Jeffrey H Lee; Jun Yu; Ralph H Hruban; Mitsuro Kanda; Marcia Irene Canto; Michael Goggins
Journal:  Clin Gastroenterol Hepatol       Date:  2014-12-04       Impact factor: 11.382

10.  Interleukin-6 is required for pancreatic cancer progression by promoting MAPK signaling activation and oxidative stress resistance.

Authors:  Yaqing Zhang; Wei Yan; Meredith A Collins; Filip Bednar; Sabita Rakshit; Bruce R Zetter; Ben Z Stanger; Ivy Chung; Andrew D Rhim; Marina Pasca di Magliano
Journal:  Cancer Res       Date:  2013-10-04       Impact factor: 12.701
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