| Literature DB >> 22226616 |
Hong Yang1, Kun Zheng, Zuoming Zhang, Wei Shi, Shubo Jing, Li Wang, Wei Zheng, Dazhou Zhao, Jianing Xu, Ping Zhang.
Abstract
Ordered MCM-41-type mesoporous silica nanoparticles (MSNs) with pore size of 2.6 nm were synthesized and were further modified with various amounts of 3-aminopropyltriethoxysilane (APTES), respectively, by a direct co-condensation method. These amine functionalized mesoporous silica nanoparticles (Am-MSNs) were employed to complex with plasmid DNA (pDNA) to study their adsorption and protection capacities. The results demonstrate the MSNs functionalized with aminopropyl groups present advanced adsorption capacities for pDNA immobilization. And Am-MSNs with high APTES amount lead to high amount of pDNA adsorption. Further investigation of pDNA protection shows that Am-MSNs with moderate APTES amount could completely protect pDNA from enzymatic degradation, while those with smaller and/or higher amount of APTES could partially provide protection of pDNA.Entities:
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Year: 2011 PMID： 22226616 DOI： 10.1016/j.jcis.2011.12.043
Source DB: PubMed Journal: J Colloid Interface Sci ISSN： 0021-9797 Impact factor: 8.128