| Literature DB >> 22225638 |
Werner J Geldenhuys1, Max O Funk, Cornelis J Van der Schyf, Richard T Carroll.
Abstract
Monoamine oxidase B (MAO-B) inhibitors are used to treat Parkinson's disease. In this study, we searched for novel MAO-B inhibitors using a scaffold hopping approach based on our experience with the thiazolidinedione (TZD) class of compounds as MAO-B inhibitors. Several novel compounds were identified, with potencies in the low nanomolar and low micromolar range. We also found that derivatives of the natural product sulfuretin are potent MAO-A and MAO-B inhibitors.Entities:
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Year: 2011 PMID： 22225638 DOI： 10.1016/j.bmcl.2011.12.056
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823